GSDMD

GSDMD
Identifiers
Aliases	GSDMD, DF5L, DFNA5L, GSDMDC1, FKSG10, gasdermin D
External IDs	MGI: 1916396 HomoloGene: 12299 GeneCards: GSDMD
Gene ontology Molecular function • protein binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidic acid binding • phosphatidylserine binding • cardiolipin binding • phosphatidylinositol-4-phosphate binding Cellular component • cytoplasm • inflammasome complex • nucleoplasm • cytosol • plasma membrane • extracellular space • NLRP3 inflammasome complex Biological process • cellular response to extracellular stimulus • innate immune response • inflammatory response • programmed cell death • immune system process • pore complex assembly • cytolysis • pore formation in membrane of other organism • defense response to Gram-negative bacterium • positive regulation of interleukin-1 beta secretion • protein homooligomerization • pyroptosis • defense response to Gram-positive bacterium Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79792	69146
Ensembl	n/a	ENSMUSG00000022575
UniProt	P57764	Q9D8T2
RefSeq (mRNA)	NM_001166237 NM_024736	NM_026960
RefSeq (protein)	NP_001159709.1 NP_079012.3	NP_081236.1
Location (UCSC)	Chr 8: 143.55 – 143.56 Mb	Chr 15: 75.86 – 75.87 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Gasdermin D is a protein that in humans is encoded by the GSDMD gene. ^[3]

Function

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Gasdermin D". Retrieved 2016-08-26.

Further reading

• Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T, Sasaki H (2009). "Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium". Genes Chromosomes Cancer. 48 (3): 261–71. doi:10.1002/gcc.20636. PMID 19051310.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.