CCDC88A

CCDC88A
Identifiers
Aliases	CCDC88A, APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, coiled-coil domain containing 88A
External IDs	MGI: 1925177 HomoloGene: 41180 GeneCards: CCDC88A
Gene ontology Molecular function • protein homodimerization activity • protein kinase B binding • phosphatidylinositol binding • actin binding • microtubule binding Cellular component • cytoplasm • Golgi apparatus • cell projection • cytoplasmic, membrane-bounded vesicle • endoplasmic reticulum • lamellipodium • membrane • cytoplasmic vesicle • cytosol • plasma membrane • cell leading edge Biological process • regulation of actin cytoskeleton organization • nervous system development • DNA replication • membrane organization • cell migration • lamellipodium assembly • activation of protein kinase B activity • regulation of DNA replication • TOR signaling • regulation of protein phosphorylation • regulation of cell proliferation • regulation of neuron projection development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55704	108686
Ensembl	ENSG00000115355	ENSMUSG00000032740
UniProt	Q3V6T2	Q5SNZ0
RefSeq (mRNA)	NM_001135597 NM_001254943 NM_018084	NM_176841
RefSeq (protein)	NP_001129069.1 NP_001241872.1 NP_060554.3	NP_789811.2
Location (UCSC)	Chr 2: 55.29 – 55.42 Mb	Chr 11: 29.37 – 29.51 Mb
PubMed search	[1]	[2]
Wikidata

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Girdin is a protein that in humans is encoded by the CCDC88A gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem. 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.
4. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem. 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.
5. "Entrez Gene: KIAA1212 KIAA1212".

External links

• DISC1 Players Gird For Adult Neurodevelopment - Schizophrenia Research Forum, 8 oct 2009

Further reading

• Kitamura T, Asai N, Enomoto A, et al. (2008). "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.". Nat. Cell Biol. 10 (3): 329–37. doi:10.1038/ncb1695. PMID 18264090.
• Enomoto A, Murakami H, Asai N, et al. (2005). "Akt/PKB regulates actin organization and cell motility via Girdin/APE.". Dev. Cell. 9 (3): 389–402. doi:10.1016/j.devcel.2005.08.001. PMID 16139227.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1.". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.