Glutaurine

Glutaurine
Names
IUPAC name
N-(2-Sulfoethyl)-L-glutamine
Other names
γ-Glutamyltaurine; γ-L-Glutamyltaurine[1]
Identifiers
56488-60-9 YesY
3D model (Jmol) Interactive image
ChEMBL ChEMBL2106758
ChemSpider 62003
PubChem 68759
Properties
C7H14N2O6S
Molar mass 173.1897
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Glutaurine is a chemical compound which is an amide formed from glutamic acid and taurine.

Biological role


Glutaurine, an endogenous compound (KEGG: C05844), has been noted as an antiepileptic, with antiamnesia properties. The dipeptide γ-glutamyltaurine (γ-GT; glutaurine, Litoralon) was discovered in the parathyroid in 1980, and later in the mammalian brain. This led to studies on intrinsic and synthetic taurine peptides, and the suggestion that γ-glutamyltransferase (GGT; γ-glutamyl-transpeptidase) in the brain is responsible for its in vivo formation.[2]

The versatile molecule mimicks the anxiolytic drug diazepam, and is implicated in phenomena from feline aggression to amphibian metamorphosis, radiation protection and the glutamatergic system in schizophrenic disorders.[2]

References

  1. "56488-60-9 CAS Manufactory". Chemicalbook.com. Retrieved 2012-04-21.
  2. 1 2 Bittner S et al (2005) γ-L-glutamyltaurine. Amino Acids, 28(4): 343-356
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