Glypican 1

GPC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ACR, 4AD7, 4BWE, 4YWT
Identifiers
Aliases	GPC1, glypican, Glypican 1
External IDs	MGI: 1194891 HomoloGene: 20477 GeneCards: GPC1
Gene ontology Molecular function • fibroblast growth factor binding • heparan sulfate proteoglycan binding • copper ion binding • laminin binding Cellular component • endosome • membrane • proteinaceous extracellular matrix • plasma membrane • integral component of plasma membrane • extracellular space • extracellular region • lysosomal lumen • Golgi lumen • membrane raft • anchored component of membrane • extracellular exosome Biological process • glycosaminoglycan metabolic process • myelin assembly • heparan sulfate proteoglycan catabolic process • retinoid metabolic process • axon guidance • negative regulation of fibroblast growth factor receptor signaling pathway • positive regulation of skeletal muscle cell differentiation • glycosaminoglycan catabolic process • glycosaminoglycan biosynthetic process • Schwann cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2817	14733
Ensembl	ENSG00000063660	ENSMUSG00000034220
UniProt	P35052	Q9QZF2
RefSeq (mRNA)	NM_002081	NM_016696
RefSeq (protein)	NP_002072.2	NP_057905.1
Location (UCSC)	Chr 2: 240.44 – 240.47 Mb	Chr 1: 92.83 – 92.86 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Glypican-1 is a protein that in humans is encoded by the GPC1 gene.^[3][4]

Function

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.^[4]

Interactions

Glypican 1 has been shown to interact with SLIT2.^[5]

Clinical significance

This protein is involved in the misfolding of normal prion proteins in the cell membrane to the infectious prion form.^[6]

See also

• Glypican

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Vermeesch JR, Mertens G, David G, Marynen P (Jul 1995). "Assignment of the human glypican gene (GPC1) to 2q35-q37 by fluorescence in situ hybridization". Genomics. 25 (1): 327–9. doi:10.1016/0888-7543(95)80152-C. PMID 7774946.
4. "Entrez Gene: GPC1 glypican 1".
5. Ronca F, Andersen JS, Paech V, Margolis RU (August 2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. 276 (31): 29141–7. doi:10.1074/jbc.M100240200. PMID 11375980.
6. Taylor DR, Whitehouse IJ, Hooper NM (2009). Westaway, David, ed. "Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation". PLoS Pathog. 5 (11): e1000666. doi:10.1371/journal.ppat.1000666. PMC 2773931. PMID 19936054.

Further reading

• Karthikeyan L; Maurel P; Rauch U; et al. (1992). "Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican". Biochem. Biophys. Res. Commun. 188 (1): 395–401. doi:10.1016/0006-291X(92)92398-H. PMID 1417860.
• David G; Lories V; Decock B; et al. (1991). "Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts". J. Cell Biol. 111 (6 Pt 2): 3165–76. doi:10.1083/jcb.111.6.3165. PMC 2116352. PMID 2148568.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kleeff J; Ishiwata T; Kumbasar A; et al. (1998). "The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer". J. Clin. Invest. 102 (9): 1662–73. doi:10.1172/JCI4105. PMC 509114. PMID 9802880.
• Gengrinovitch S; Berman B; David G; et al. (1999). "Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165". J. Biol. Chem. 274 (16): 10816–22. doi:10.1074/jbc.274.16.10816. PMID 10196157.
• Liang Y; Annan RS; Carr SA; et al. (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". J. Biol. Chem. 274 (25): 17885–92. doi:10.1074/jbc.274.25.17885. PMID 10364234.
• Schofield KP, Gallagher JT, David G (2000). "Expression of proteoglycan core proteins in human bone marrow stroma". Biochem. J. 343 Pt 3: 663–8. doi:10.1042/0264-6021:3430663. PMC 1220599. PMID 10527946.
• Karumanchi SA; Jha V; Ramchandran R; et al. (2001). "Cell surface glypicans are low-affinity endostatin receptors". Mol. Cell. 7 (4): 811–22. doi:10.1016/S1097-2765(01)00225-8. PMID 11336704.
• Ronca F, Andersen JS, Paech V, Margolis RU (2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. 276 (31): 29141–7. doi:10.1074/jbc.M100240200. PMID 11375980.
• Matsuda K; Maruyama H; Guo F; et al. (2001). "Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells". Cancer Res. 61 (14): 5562–9. PMID 11454708.
• Alvarez K, Fadic R, Brandan E (2002). "Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy". J. Cell. Biochem. 85 (4): 703–13. doi:10.1002/jcb.10184. PMID 11968010.
• Ding K; Mani K; Cheng F; et al. (2002). "Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols". J. Biol. Chem. 277 (36): 33353–60. doi:10.1074/jbc.M203383200. PMID 12084716.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Belting M; Mani K; Jönsson M; et al. (2004). "Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivotal role for nitrosothiol-derived nitric oxide". J. Biol. Chem. 278 (47): 47181–9. doi:10.1074/jbc.M308325200. PMID 12972423.
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Watanabe N; Araki W; Chui DH; et al. (2004). "Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease". FASEB J. 18 (9): 1013–5. doi:10.1096/fj.03-1040fje. PMID 15084524.
• Li J; Kleeff J; Kayed H; et al. (2004). "Glypican-1 antisense transfection modulates TGF-beta-dependent signaling in Colo-357 pancreatic cancer cells". Biochem. Biophys. Res. Commun. 320 (4): 1148–55. doi:10.1016/j.bbrc.2004.06.063. PMID 15249209.
• Davies EJ; Blackhall FH; Shanks JH; et al. (2005). "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer". Clin. Cancer Res. 10 (15): 5178–86. doi:10.1158/1078-0432.CCR-03-0103. PMID 15297422.