Glypican 2

GPC2
Identifiers
Aliases	GPC2, Glypican 2
External IDs	MGI: 1919201 HomoloGene: 17657 GeneCards: GPC2
Gene ontology Molecular function • heparan sulfate proteoglycan binding Cellular component • membrane • proteinaceous extracellular matrix • plasma membrane • extracellular space • extracellular region • lysosomal lumen • endoplasmic reticulum • Golgi lumen • anchored component of membrane Biological process • glycosaminoglycan metabolic process • retinoid metabolic process • glycosaminoglycan catabolic process • glycosaminoglycan biosynthetic process • neuron differentiation • smoothened signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221914	71951
Ensembl	ENSG00000213420	ENSMUSG00000029510
UniProt	Q8N158	Q8BKV1
RefSeq (mRNA)	NM_152742	NM_172412
RefSeq (protein)	NP_689955.1	NP_766000.1
Location (UCSC)	Chr 7: 100.17 – 100.18 Mb	Chr 5: 138.27 – 138.28 Mb
PubMed search	[1]	[2]
Wikidata

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Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene.^[3][4]

Function

Cerebroglycan is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons.^[5] Cerebroglycan has especially high affinity for laminin-1.^[6]

See also

• Glypican

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Stipp CS, Litwack ED, Lander AD (January 1994). "Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation". J. Cell Biol. 124 (1–2): 149–160. doi:10.1083/jcb.124.1.149. PMC 2119891. PMID 8294498.
4. "Entrez Gene: GPC2 glypican 2".
5. Ivins JK, Litwack ED, Kumbasar A, Stipp CS, Lander AD (April 1997). "Cerebroglycan, a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones". Dev. Biol. 184 (2): 320–332. doi:10.1006/dbio.1997.8532. PMID 9133438.
6. Herndon ME, Stipp CS, Lander AD (February 1999). "Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding". Glycobiology. 9 (2): 143–155. doi:10.1093/glycob/9.2.143. PMID 9949192.

External links

• GPC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)