HLA-DR51
 | |
| major histocompatibility complex, class II, DR51 | |
| Haplotypes groups | DRA*01:DRB5*01 DRA*01:DRB5*02 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 5 *01 *02 |
| Symbol(s) | HLA-DRB5 |
| EBI-HLA | DRB5*01 |
| EBI-HLA | DRB5*02 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution.[1] having diverged from DRB1 approximately 4 million years ago.[2]
DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.
Alleles
| DRB5* | DR51 | ? | Sample |
| allele | % | % | size (N) |
| 0101 | >71 | 28 | |
| 0102 | >86 | 8 | |
| 0202 | >86 | 13 | |
DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.
DRB5*01 allele group
- 14 Alleles: 11 proteins, 2 Nulls
- DR51 Serotype: *0101, *0102
- Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
- Nulls: *0108N, *0110N
DRB5*02 allele group
- 4 Alleles: 4 proteins
- DR51 Serotype: *0202,
- Serotype unknown: *0203 to *0205
Associated diseases
DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:
DRB5*0101:DRB1*1501 Multiple sclerosis,[4] leprosy[5]
DRB1 linkage
HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.
References
- ↑ Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic". Immunogenetics. 25 (6): 397–402. doi:10.1007/BF00396106. PMID 3596674.
- ↑ Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23–31. doi:10.1016/S0198-8859(96)00189-9. PMID 8911994.
- ↑ derived from IMGT/HLA
- ↑ Sospedra M, Muraro P, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R (2006). "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.". J Immunol. 176 (3): 1951–61. doi:10.4049/jimmunol.176.3.1951. PMC 2746197
. PMID 16424227. - ↑ Joko S, Numaga J, Kawashima H, Namisato M, Maeda H (2000). "Human leukocyte antigens in forms of leprosy among Japanese patients.". Int J Lepr Other Mycobact Dis. 68 (1): 49–56. PMID 10834069.