HPE
HPE may refer to:
- Lancia Beta HPE, introduced 1975
- Lancia Delta HPE, introduced 1995
- Hennessey Performance Engineering
- Hewlett Packard Enterprise
- High Point Enterprise, a newspaper
- High-pressure electrolysis
- Holoprosencephaly, a cephalic disorder
- Hope (Flintshire) railway station, in Wales
- United Alignment of Nationalists (Greek: Ηνωμένη Παράταξις Εθνικοφρόνων), a Greek political alliance
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