HSD17B2

HSD17B2
Identifiers
Aliases	HSD17B2, EDH17B2, HSD17, SDR9C2, hydroxysteroid (17-beta) dehydrogenase 2, hydroxysteroid 17-beta dehydrogenase 2
External IDs	MGI: 1096386 HomoloGene: 99709 GeneCards: HSD17B2
EC number	1.1.1.239
Gene ontology Molecular function • oxidoreductase activity • estradiol 17-beta-dehydrogenase activity • testosterone dehydrogenase (NAD+) activity • 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane Biological process • in utero embryonic development • oxidation-reduction process • response to retinoic acid • steroid biosynthetic process • placenta development • lipid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3294	15486
Ensembl	ENSG00000086696	ENSMUSG00000031844
UniProt	P37059	P51658
RefSeq (mRNA)	NM_002153	NM_008290
RefSeq (protein)	NP_002144.1	NP_032316.2
Location (UCSC)	Chr 16: 82.04 – 82.1 Mb	Chr 8: 117.7 – 117.76 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Durocher F, Morissette J, Labrie Y, Labrie F, Simard J (Feb 1995). "Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2". Genomics. 25 (3): 724–6. doi:10.1016/0888-7543(95)80017-G. PMID 7759109.
4. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Mar 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1-3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
5. "Entrez Gene: HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2".

Further reading

• Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F (Oct 1995). "The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species". DNA and Cell Biology. 14 (10): 849–61. doi:10.1089/dna.1995.14.849. PMID 7546291.
• Andersson S, Geissler WM, Patel S, Wu L (Jun 1995). "The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases". The Journal of Steroid Biochemistry and Molecular Biology. 53 (1-6): 37–9. doi:10.1016/0960-0760(95)00039-3. PMID 7626483.
• Carsol JL, Martin PM, de Launoit Y (Oct 1994). "Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors". Neuroendocrinology. 60 (4): 445–51. doi:10.1159/000126779. PMID 7824086.
• Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S (Jun 1993). "Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity". The Journal of Biological Chemistry. 268 (17): 12964–9. PMID 8099587.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Zhang Y, Word RA, Fesmire S, Carr BR, Rainey WE (Oct 1996). "Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3". The Journal of Clinical Endocrinology and Metabolism. 81 (10): 3594–8. doi:10.1210/jc.81.10.3594. PMID 8855807.
• Moghrabi N, Head JR, Andersson S (Nov 1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver". The Journal of Clinical Endocrinology and Metabolism. 82 (11): 3872–8. doi:10.1210/jc.82.11.3872. PMID 9360554.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Corbould AM, Judd SJ, Rodgers RJ (Jan 1998). "Expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women". The Journal of Clinical Endocrinology and Metabolism. 83 (1): 187–94. doi:10.1210/jc.83.1.187. PMID 9435439.
• Dong Y, Qiu QQ, Debear J, Lathrop WF, Bertolini DR, Tamburini PP (Oct 1998). "17Beta-hydroxysteroid dehydrogenases in human bone cells". Journal of Bone and Mineral Research. 13 (10): 1539–46. doi:10.1359/jbmr.1998.13.10.1539. PMID 9783542.
• Kitawaki J, Koshiba H, Ishihara H, Kusuki I, Tsukamoto K, Honjo H (Sep 2000). "Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium". The Journal of Clinical Endocrinology and Metabolism. 85 (9): 3292–6. doi:10.1210/jc.85.9.3292. PMID 10999824.
• Sano T, Hirasawa G, Takeyama J, Darnel AD, Suzuki T, Moriya T, Kato K, Sekine H, Ohara S, Shimosegawa T, Nakamura J, Yoshihama M, Harada N, Sasano H (Nov 2001). "17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract". Clinical Science. 101 (5): 485–91. doi:10.1042/CS20010052. PMID 11672453.
• Lu ML, Huang YW, Lin SX (Jun 2002). "Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2". The Journal of Biological Chemistry. 277 (25): 22123–30. doi:10.1074/jbc.M111726200. PMID 11940569.
• Provost PR, Blomquist CH, Drolet R, Flamand N, Tremblay Y (Aug 2002). "Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation". The Journal of Clinical Endocrinology and Metabolism. 87 (8): 3883–92. doi:10.1210/jc.87.8.3883. PMID 12161528.
• Oliveira IO, Lhullier C, Brum IS, Spritzer PM (Sep 2003). "Gene expression of type 2 17 beta hydroxysteroid dehydrogenase in scalp hairs of hirsute women". Steroids. 68 (7-8): 641–9. doi:10.1016/S0039-128X(03)00093-X. PMID 12957669.
• Oduwole OO, Mäkinen JM, Isomaa VV, Karttunen TJ, Vihko PT (2004). "Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues". Anticancer Research. 23 (5A): 3889–97. PMID 14666693.
• Matsuzaki S, Canis M, Pouly JL, Déchelotte PJ, Mage G (Feb 2006). "Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection". Fertility and Sterility. 85 (2): 308–13. doi:10.1016/j.fertnstert.2005.08.017. PMID 16595205.