Hematoxylin body

In diagnostic pathology, a hematoxylin body, or LE body, is a dense, homogeneous, basophilic particle, easily stainable with hematoxylin. It consists of degraded nuclear material from an injured cell, along with autoantibodies and a limited amount of cytoplasm.[1][2][3]

Hematoxylin bodies occur in systemic lupus erythematosus. The hematoxylin body may be green, blue, or purple with the Papanicolaou stain and magenta with Romanowsky stains.[4] The material has a positive Feulgen stain reaction, which is typical of DNA.[5] The material may be extracellular or may be ingested by leukocytes, which are then known as LE cells.[2][6][7]

References

  1. ↑ Chan JK (2014). "The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology". Int. J. Surg. Pathol. 22 (1): 12–32. doi:10.1177/1066896913517939. PMID 24406626.
  2. 1 2 Hematoxylin body. Medical Dictionary.
  3. ↑ Moreland, LW. Rheumatology and Immunology Therapy Springer Berlin Heidelberg 2004 page 384 ISBN 9783540206255 doi:10.1007/3-540-29662-X_1191
  4. ↑ Cibas ES, Ducatman BS. Cytology: Diagnostic Principles and Clinical Correlates. Elsevier Health Sciences. 2013. Pages 132-133 ISBN 9781455750795
  5. ↑ Hollander JL. Arthritis and allied conditions: a textbook of rheumatology. 1966 Page 100 and 784
  6. ↑ Wallace DJ, Hahn B. (editors). Dubois' Lupus Erythematosus. Lippincott Williams & Wilkins, 2007. ISBN 9780781793940
  7. ↑ Robbins & Cotran Pathologic Basis of Disease. Vinay Kumar V, Abbas AK, Aster JC. Elsevier Health Sciences, 2014. Edition 9, revised. pages 222 and 225. ISBN 9780323296359

External links

This article is issued from Wikipedia - version of the 6/22/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.