Homospermidine synthase
| Homospermidine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.44 | ||||||||
| CAS number | 76106-84-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Homospermidine synthase (EC 2.5.1.44) is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (1) 2 putrescine sym-homospermidine + NH3 + H+
- (2) putrescine + spermidine sym-homospermidine + propane-1,3-diamine
The reaction of this enzyme occurs in three steps.
References
- ↑ Tait, G.H. (1979). "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis". Biochem. Soc. Trans. 7 (1): 199–200. PMID 437275.
- ↑ Böttcher, F.; Ober, D.; Hartmann, T. (1994). "Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation". Can. J. Chem. 72: 80–85. doi:10.1139/v94-013.
- ↑ Yamamoto, S.; Nagata, S.; Kusaba, K. (1993). "Purification and characterization of homospermidine synthase in Acinetobacter tartarogens ATCC 31105". J. Biochem. 114 (1): 45–49. PMID 8407874.
- ↑ Srivenugopal, K.S.; Adiga, P.R. (1980). "Enzymatic synthesis of sym-homospermidine in Lathyrus sativus T (grass pea) seedlings". Biochem. J. 190 (2): 461–464. PMC 1162113
. PMID 7470060. - ↑ Ober, D.; Tholl, D.; Martin, W.; Hartmann, T. (1996). "Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli". J. Gen. Appl. Microbiol. 42 (5): 411–419. doi:10.2323/jgam.42.411.
- ↑ Ober, D.; Hartmann, T. (1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proc. Natl. Acad. Sci. USA. 96 (26): 14777–14782. Bibcode:1999PNAS...9614777O. doi:10.1073/pnas.96.26.14777. PMC 24724. PMID 10611289.
External links
- Homospermidine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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