Hyaladherin

Hyaladherins, also known as hyaluronan-binding proteins, are proteins capable of binding to hyaluronic acid. Most hyaladherins belong to the Link module superfamily, including its main receptor CD44, hyalectans and TSG-6.[1] In addition there is a diverse group of hyaladherins lacking a Link module; these include the receptor RHAMM, C1QBP (HABP1) and HABP2.[2] The primary roles of hyaladherins are cell adhesion, structural support of the extracellular matrix (ECM) and cell signalling.[2]

Due to the role of aberrant hyaluronic acid synthesis and degradation in various cancers, hyaladherins, as well as hyaluronic acid, are considered a promising target for cancer therapy.[3]

See also

References

  1. ↑ Toole, B.P. (October 1990). "Hyaluronan and its binding proteins, the hyaladherins". Current Opinion in Cell Biology. 2 (5): 839–844. doi:10.1016/0955-0674(90)90081-O.
  2. 1 2 Day, A. J.; Prestwich, G. D. (20 November 2001). "Hyaluronan-binding Proteins: Tying Up the Giant". Journal of Biological Chemistry. 277 (7): 4585–4588. doi:10.1074/jbc.R100036200.
  3. ↑ Nikitovic, Dragana; Kouvidi, Katerina; Kavasi, Rafaela-Maria; Berdiaki, Aikaterini; N. Tzanakakis, George (21 May 2016). "Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer". Current Drug Delivery. 13 (4): 500–511. doi:10.2174/1567201813666151109103013.
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