Hypermagnesemia

Hypermagnesemia
Magnesium
Classification and external resources
Specialty endocrinology, disorder of magnesium metabolism[*]
ICD-10 E83.4
ICD-9-CM 275.2
DiseasesDB 6259
eMedicine med/3383 emerg/262 ped/1080

Hypermagnesemia is an electrolyte disturbance in which there is a high level of magnesium in the blood.[1] It is defined as a level greater than 1.1 mmol/L.[2] Symptoms include weakness, confusion, decreased breathing rate, and cardiac arrest.[2]

Hypermagnesemia can occur in kidney failure and those who are given magnesium salts or who take drugs that contain magnesium (e.g. some antacids and laxatives).[3] It is usually concurrent with other electrolyte disturbances such as a low blood calcium and/or high blood potassium level. Specific electrocardiogram (ECG) changes may be present.[2]

Treatment when levels are very high include calcium chloride, intravenous normal saline with furosemide, and hemodialysis.[2]

Hypermagnesemia occurs rarely because the kidney is very effective in excreting excess magnesium.

Signs and symptoms

Abnormal heart rhythms and asystole are possible complications of hypermagnesemia related to the heart. Magnesium acts as a physiologic calcium blocker, which results in electrical conduction abnormalities within the heart.

Clinical consequences related to serum concentration:

Note that the therapeutic range for the prevention of the pre-eclampsic uterine contractions is: 4.0-7.0 mEq/L.[4] As per Lu and Nightingale,[5] serum Mg2+ concentrations associated with maternal toxicity (also neonate depression - hypotonia and low Apgar scores) are:

Hypermagnesemia in kidney failure

An evaluation of 515 patients on hemodialysis demonstrated that serum magnesium concentration lower than 2.77 mg/dL (1.14 mmol/L) is a significant predictor for increased all-cause mortality. While the mean serum magnesium concentration of this study population (2.77 mg/dL or 1.14 mmol/L) would be considered indicative of mild hypermagnesemia in the healthy population, serum magnesium concentrations in hemodialysis patients may be optimal at a higher concentration, in view of better survival under hemodialysis conditions, without causing severe and symptomatic hypermagnesemia.[6] Consistently, lower magnesium levels were significantly associated with the presence of vascular calcification of the hand arteries in a study investigating 390 nondiabetic hemodialysis patients. These results suggest that higher serum magnesium concentrations may play an important protective role in the development of vascular calcification in hemodialysis patients.[7] Results from a longitudinal study with end-stage renal disease patients suggest that hypermagnesemia may retard the development of arterial calcifications in end-stage renal disease.[8] Significantly lower values of carotid intima-media thickness and aortic pulse wave velocity values, which are surrogate markers for vascular calcification, were observed in chronic kidney disease patients with high serum magnesium levels (0.90-1.32 mmol/L or 2.18-3.21 mg/dL) indicating a lower arteriosclerotic burden associated with a lower risk of cardiovascular events and mortality.[9] Consequently, CKD patients with mildly elevated magnesium levels could have a survival advantage over those with lower magnesium levels.[10]

Causes

Magnesium status depends on three organs: uptake in the intestine, storage in the bone and excretion in the kidneys. Hypermagnesemia is therefore often due to problems in these organs, mostly intestine or kidney.[11]

Predisposing conditions

Metabolism

For a detailed description of magnesium homeostasis and metabolism see hypomagnesemia.

Treatment

Prevention of hypermagnesemia usually is possible. In mild cases, withdrawing magnesium supplementation is often sufficient. In more severe cases the following treatments are used:

Definitive treatment of hypermagnesemia requires increasing renal magnesium excretion through:

References

  1. ↑ "hypermagnesemia" at Dorland's Medical Dictionary
  2. 1 2 3 4 Soar, J; Perkins, GD; Abbas, G; Alfonzo, A; Barelli, A; Bierens, JJ; Brugger, H; Deakin, CD; Dunning, J; Georgiou, M; Handley, AJ; Lockey, DJ; Paal, P; Sandroni, C; Thies, KC; Zideman, DA; Nolan, JP (October 2010). "European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution.". Resuscitation. 81 (10): 1400–33. PMID 20956045.
  3. ↑ Romani, Andrea, M.P. (2013). "Chapter 3. Magnesium in Health and Disease". In Astrid Sigel; Helmut Sigel; Roland K. O. Sigel. Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 49–79. doi:10.1007/978-94-007-7500-8_3.
  4. ↑ Pritchard JA. The use of the magnesium ion in the management of eclamptogenic toxemias. Surg Gynecol Obstet. 1955; 100:131–140
  5. ↑ Lu JF,Nightingale CH. Magnesium sulfate in eclampsia and pre-eclampsia. Clin Pharmacokinet. 2000; 38:305–314
  6. ↑ Ishimura E, Okuno S, Yamakawa T, et al. (2007). "Serum magnesium concentration is a significant predictor of mortality in maintenance hemodialysis patients" (PDF). Magnes Res. 20: 237–244. doi:10.1684/mrh.2007.0116. PMID 18271493.
  7. ↑ Ishimura E, Okuno S, Kitatani K, et al. (2007). "Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients". Clin Nephrol. 68: 222–227. doi:10.5414/cnp68222. PMID 17969489.
  8. ↑ Meema HE, Oreopoulos DG, Rapoport A (1987). "Serum magnesium level and arterial calcification in end-stage renal disease". Kidney Int. 32: 388–394. doi:10.1038/ki.1987.222. PMID 3669498.
  9. ↑ Salem S, Bruck H, Bahlmann FH, et al. (2012). "Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification". Am J Nephrol. 35: 31–39. doi:10.1159/000334742. PMID 22179063.
  10. ↑ Massy ZA, Drüeke TB (2012). "Magnesium and outcomes in patients with chronic kidney disease: focus on vascular calcification, atherosclerosis, and survival" (PDF). Clin Kidney J. 5 (Suppl 1): i52–i61. doi:10.1093/ndtplus/sfr167.
  11. ↑ Jahnen-Dechent W, Ketteler M (2012). "Magnesium basics" (PDF). Clin Kidney J. 5 (Suppl 1): i3–i14. doi:10.1093/ndtplus/sfr163.
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