IFT74

IFT74
Identifiers
Aliases	IFT74, CCDC2, CMG-1, CMG1, intraflagellar transport 74
External IDs	MGI: 1914944 HomoloGene: 11831 GeneCards: IFT74
Gene ontology Molecular function • chromatin binding • beta-tubulin binding Cellular component • intraciliary transport particle B • centrosome • cell projection • cilium • cytoplasmic, membrane-bounded vesicle • ciliary tip • motile cilium • primary cilium • cytoplasmic vesicle • nucleus Biological process • Notch signaling pathway • cilium morphogenesis • intraciliary transport • intraciliary transport involved in cilium assembly • heart development • keratinocyte development • determination of left/right symmetry • cell projection organization • epidermis development • negative regulation of epithelial cell proliferation • cilium assembly • positive regulation of cell adhesion mediated by integrin • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80173	67694
Ensembl	ENSG00000096872	ENSMUSG00000028576
UniProt	Q96LB3	Q8BKE9
RefSeq (mRNA)	NM_001099222 NM_001099223 NM_001099224 NM_025103	NM_001290568 NM_026319
RefSeq (protein)	NP_001092692.1 NP_001092693.1 NP_001092694.1 NP_079379.2	NP_001277497.1 NP_080595.2
Location (UCSC)	Chr 9: 26.95 – 27.06 Mb	Chr 4: 94.61 – 94.69 Mb
PubMed search	[1]	[2]
Wikidata

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Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.^[3][4]

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".
4. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell. Sci. 114 (Pt 15): 2755–73. PMID 11683410.

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Xiao S, Sato C, Kawarai T, et al. (2008). "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.". Neurobiol. Aging. 29 (8): 1279–82. doi:10.1016/j.neurobiolaging.2007.02.022. PMID 17383054.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.