IGF2BP2

IGF2BP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQH
Identifiers
Aliases	IGF2BP2, IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2
External IDs	MGI: 1890358 HomoloGene: 4774 GeneCards: IGF2BP2
Genetically Related Diseases
type 2 diabetes mellitus, gestational diabetes[1]
Gene ontology Molecular function • nucleotide binding • poly(A) RNA binding • mRNA 5'-UTR binding • protein binding • mRNA binding • translation regulator activity • RNA binding • mRNA 3'-UTR binding • nucleic acid binding Cellular component • cytoplasm • cytosol • cytoskeleton • nucleus Biological process • transport • regulation of cytokine biosynthetic process • anatomical structure morphogenesis • negative regulation of translation • mRNA transport • gene expression • regulation of translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10644	319765
Ensembl	ENSG00000073792	ENSMUSG00000033581
UniProt	Q9Y6M1	Q5SF07
RefSeq (mRNA)	NM_001007225 NM_001291869 NM_001291872 NM_001291873 NM_001291874 NM_001291875 NM_006548	NM_183029
RefSeq (protein)	NP_001007226.1 NP_001278798.1 NP_001278801.1 NP_001278802.1 NP_001278803.1 NP_001278804.1 NP_006539.3	NP_898850.2
Location (UCSC)	Chr 3: 185.64 – 185.83 Mb	Chr 16: 22.06 – 22.16 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.^[4][5][6]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

References

1. "Diseases that are genetically associated with IGF2BP2 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Zhang JY, Chan EK, Peng XX, Tan EM (May 1999). "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma". J Exp Med. 189 (7): 1101–10. doi:10.1084/jem.189.7.1101. PMC 2193003. PMID 10190901.
5. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. PMC 116055. PMID 9891060.
6. "Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2".

Further reading

• Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.". Biol. Cell. 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).". Biol. Chem. 384 (1): 25–37. doi:10.1515/BC.2003.004. PMID 12674497.
• Brants JR, Ayoubi TA, Chada K, et al. (2004). "Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2.". FEBS Lett. 569 (1–3): 277–83. doi:10.1016/j.febslet.2004.05.075. PMID 15225648.
• Ping S, Wang S, Zhang J, Peng X (2005). "Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells". Int. J. Biochem. Cell Biol. 37 (3): 616–27. doi:10.1016/j.biocel.2004.08.007. PMID 15618018.
• Hammer NA, Hansen TO, Byskov AG, et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer". Reproduction. 130 (2): 203–12. doi:10.1530/rep.1.00664. PMID 16049158.
• Natkunam Y, Vainer G, Chen J, et al. (2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms". Haematologica. 92 (2): 176–83. doi:10.3324/haematol.10724. PMID 17296566.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Cleynen I, Brants JR, Peeters K, et al. (2007). "HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB". Mol. Cancer Res. 5 (4): 363–72. doi:10.1158/1541-7786.MCR-06-0331. PMID 17426251.