INTS1

INTS1
Identifiers
Aliases INTS1, INT1, NET28, integrator complex subunit 1
External IDs MGI: 1915760 HomoloGene: 53111 GeneCards: INTS1
Orthologs
Species Human Mouse
Entrez

26173

68510

Ensembl

ENSG00000164880

ENSMUSG00000029547

UniProt

Q8N201

Q6P4S8

RefSeq (mRNA)

NM_001080453

NM_026748

RefSeq (protein)

NP_001073922.2

NP_081024.3

Location (UCSC) Chr 7: 1.47 – 1.5 Mb Chr 5: 139.75 – 139.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. [3]

Function

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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