ITGA8

ITGA8
Identifiers
Aliases	ITGA8
External IDs	MGI: 109442 HomoloGene: 37396 GeneCards: ITGA8
Genetically Related Diseases
periodontitis, Parkinson's disease[1]
Gene ontology Molecular function • metal ion binding Cellular component • integral component of membrane • perikaryon • membrane • postsynaptic density • focal adhesion • integrin alpha8-beta1 complex • plasma membrane • apical part of cell • cell surface • integrin complex • endoplasmic reticulum • dendritic spine membrane Biological process • single organismal cell-cell adhesion • positive regulation of transforming growth factor beta receptor signaling pathway • cell differentiation • kidney development • establishment of protein localization • extracellular matrix organization • memory • nervous system development • multicellular organism development • brain development • cell adhesion • cell projection organization • inner ear morphogenesis • positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation • smooth muscle tissue development • mesodermal cell differentiation • integrin-mediated signaling pathway • substrate adhesion-dependent cell spreading • cell-matrix adhesion • metanephros development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8516	241226
Ensembl	ENSG00000077943	ENSMUSG00000026768
UniProt	P53708	A2ARA8
RefSeq (mRNA)	NM_001291494 NM_003638	NM_001001309
RefSeq (protein)	NP_003629.2	NP_001001309.1
Location (UCSC)	Chr 10: 15.51 – 15.72 Mb	Chr 2: 12.11 – 12.3 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^[4][5]

References

1. "Diseases that are genetically associated with ITGA8 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. PMID 7768999.
5. "Entrez Gene: ITGA8 integrin, alpha 8".

Further reading

• Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467.
• Denda S, Müller U, Crossin KL, et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.". Biochemistry. 37 (16): 5464–74. doi:10.1021/bi9727489. PMC 2710129. PMID 9548928.
• Hartner A, Schöcklmann H, Pröls F, et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.". Kidney Int. 56 (4): 1468–80. doi:10.1046/j.1523-1755.1999.00662.x. PMID 10504498.
• Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1.". Nat. Genet. 24 (4): 424–8. doi:10.1038/74286. PMID 10742111.
• Brandenberger R, Schmidt A, Linton J, et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney.". J. Cell Biol. 154 (2): 447–58. doi:10.1083/jcb.200103069. PMC 2150762. PMID 11470831.
• Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.". J. Histochem. Cytochem. 49 (11): 1341–50. doi:10.1177/002215540104901102. PMID 11668187.
• Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8090–5. doi:10.1073/pnas.122229199. PMC 123025. PMID 12060755.
• Lu M, Munger JS, Steadele M, et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1.". J. Cell. Sci. 115 (Pt 23): 4641–8. doi:10.1242/jcs.00145. PMID 12415008.
• Bieritz B, Spessotto P, Colombatti A, et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.". Kidney Int. 64 (1): 119–27. doi:10.1046/j.1523-1755.2003.00057.x. PMID 12787402.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8).". Matrix Biol. 23 (7): 487–96. doi:10.1016/j.matbio.2004.08.005. PMID 15579315.
• Scherberich A, Tucker RP, Degen M, et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.". Oncogene. 24 (9): 1525–32. doi:10.1038/sj.onc.1208342. PMID 15592496.

External links

• ITGA8 Info with links in the Cell Migration Gateway