ITIH2

ITIH2
Identifiers
Aliases	ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
External IDs	MGI: 96619 HomoloGene: 1668 GeneCards: ITIH2
Gene ontology Molecular function • peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • blood microparticle • extracellular exosome • extracellular region Biological process • hyaluronan metabolic process • negative regulation of peptidase activity • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3698	16425
Ensembl	ENSG00000151655	ENSMUSG00000037254
UniProt	P19823	Q61703
RefSeq (mRNA)	NM_002216	NM_010582
RefSeq (protein)	NP_002207.2	NP_034712.2
Location (UCSC)	Chr 10: 7.7 – 7.75 Mb	Chr 2: 10.09 – 10.13 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.^[3][4][5]

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

See also

• Inter-alpha-trypsin inhibitor
• ITIH1
• ITIH3
• ITIH4

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
4. Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.
5. "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2".

Further reading

• Malki N, Balduyck M, Maes P, et al. (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A.". Biol. Chem. Hoppe-Seyler. 373 (10): 1009–18. doi:10.1515/bchm3.1992.373.2.1009. PMID 1384548.
• Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI.". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi:10.1073/pnas.84.23.8272. PMC 299524. PMID 2446322.
• Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1988). "Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex.". FEBS Lett. 229 (1): 63–7. doi:10.1016/0014-5793(88)80798-1. PMID 2450046.
• Salier JP, Diarra-Mehrpour M, Sesboüé R, et al. (1989). "Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain.". Biol. Chem. Hoppe-Seyler. 369 Suppl: 15–8. PMID 2462430.
• Diarra-Mehrpour M, Bourguignon J, Sesboüé R, et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.". Eur. J. Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.
• Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.". J. Biol. Chem. 264 (27): 15975–81. PMID 2476436.
• Schreitmüller T, Hochstrasser K, Reisinger PW, et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins.". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330.
• Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor.". J. Biol. Chem. 268 (35): 26725–30. PMID 7504674.
• Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.". Eur. J. Biochem. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643.
• Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J (1994). "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor.". Biochemistry. 33 (23): 7423–9. doi:10.1021/bi00189a049. PMID 7516184.
• Enghild JJ, Salvesen G, Thøgersen IB, et al. (1993). "Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin.". J. Biol. Chem. 268 (12): 8711–6. PMID 7682553.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Mizon C, Balduyck M, Albani D, et al. (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains.". J. Immunol. Methods. 190 (1): 61–70. doi:10.1016/0022-1759(95)00257-X. PMID 8601712.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Olsen EH, Rahbek-Nielsen H, Thogersen IB, et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.". Biochemistry. 37 (1): 408–16. doi:10.1021/bi971137d. PMID 9425062.
• Mizushima S, Nii A, Kato K, Uemura A (1998). "Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues.". Biol. Pharm. Bull. 21 (2): 167–9. doi:10.1248/bpb.21.167. PMID 9514613.
• Flahaut C, Capon C, Balduyck M, et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains.". Biochem. J. 333 (3): 749–56. PMC 1219641. PMID 9677337.
• Hamm A, Veeck J, Bektas N, et al. (2008). "Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis.". BMC Cancer. 8 (25): 25. doi:10.1186/1471-2407-8-25. PMC 2268946. PMID 18226209.