IZUMO1

IZUMO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JKD, 5F4T, 5JKC, 5JK9, 5JKE, 5F4V, 5F4E
Identifiers
Aliases	IZUMO1, IZUMO, OBF, izumo sperm-egg fusion 1
External IDs	MGI: 1920706 HomoloGene: 77701 GeneCards: IZUMO1
Gene ontology Molecular function • receptor binding • protein homodimerization activity • protein binding involved in heterotypic cell-cell adhesion • protein binding Cellular component • acrosomal vesicle • membrane • acrosomal membrane • integral component of membrane • plasma membrane Biological process • cell adhesion • sperm-egg recognition • single fertilization • fusion of sperm to egg plasma membrane • heterotypic cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284359	73456
Ensembl	ENSG00000182264	ENSMUSG00000064158
UniProt	Q8IYV9	Q9D9J7
RefSeq (mRNA)	NM_182575 NM_001321864 NM_001321865	NM_001018013
RefSeq (protein)	NP_872381.2 NP_001308794.1	NP_001018013.1
Location (UCSC)	Chr 19: 48.74 – 48.75 Mb	Chr 7: 45.62 – 45.63 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Izumo sperm-egg fusion 1 is a protein that in humans is encoded by the IZUMO1 gene.^[3]

Function

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Izumo sperm-egg fusion 1".
4. Inoue N, Ikawa M, Isotani A, Okabe M (2005). "The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs". Nature. 434 (7030): 234–8. doi:10.1038/nature03362. PMID 15759005.

Further reading

• Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T, Ngwa JS, Qi Q, Curhan GC, Rimm EB, Hunter DJ, Pasquale LR, Ridker PM, Hu FB, Chasman DI, Qi L (2013). "Novel locus including FGF21 is associated with dietary macronutrient intake". Human Molecular Genetics. 22 (9): 1895–902. doi:10.1093/hmg/ddt032. PMC 3612009. PMID 23372041.
• Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (2006). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Hum. Mol. Genet. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.
• Granados-Gonzalez V, Aknin-Seifer I, Touraine RL, Chouteau J, Wolf JP, Levy R (2008). "Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure". Fertil. Steril. 90 (4): 1246–8. doi:10.1016/j.fertnstert.2007.09.008. PMID 18082733.
• Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P (2009). "Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm". Mol. Reprod. Dev. 76 (12): 1188–99. doi:10.1002/mrd.21092. PMC 3779078. PMID 19658160.
• Grayson P, Civetta A (2012). "Positive Selection and the Evolution of izumo Genes in Mammals". Int J Evol Biol. 2012: 958164. doi:10.1155/2012/958164. PMC 3432370. PMID 22957301.
• Inoue N, Ikawa M, Okabe M (2008). "Putative sperm fusion protein IZUMO and the role of N-glycosylation". Biochem. Biophys. Res. Commun. 377 (3): 910–4. doi:10.1016/j.bbrc.2008.10.073. PMID 18952059.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.