Icosanoyl-CoA synthase

Icosanoyl-CoA synthase
Identifiers
EC number	2.3.1.119
CAS number	141256-55-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, an icosanoyl-CoA synthase (EC 2.3.1.119) is an enzyme that catalyzes the chemical reaction

stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H⁺ $\rightleftharpoons$ icosanoyl-CoA + CO₂ + CoA + 2 NAD(P)+ + H₂O

The 5 substrates of this enzyme are stearoyl-CoA, malonyl-CoA, NADH, NADPH, and H⁺, whereas its 6 products are icosanoyl-CoA, CO₂, CoA, NAD⁺, NADP⁺, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Other names in common use include acyl-CoA elongase, C18-CoA elongase, and stearoyl-CoA elongase.

References

• Bessoule JJ, Lessire R, Cassagne C (1989). "Partial purification of the acyl-CoA elongase of Allium porrum leaves". Arch. Biochem. Biophys. 268 (2): 475–84. doi:10.1016/0003-9861(89)90315-9. PMID 2913944.
• Bessoule JJ, Lessire R, Rigoulet M, Guerin B, Cassagne C (1987). "Fatty acid synthesis in mitochondria from Saccharomyces cerevisiae". FEBS Lett. 214 (1): 158–62. doi:10.1016/0014-5793(87)80033-9. PMID 3552725.
• Lessire R, Bessoule JJ, Cassagne C (1985). "Solubilization of C18 CoA and C20 CoA elongases from Allium porrum L. epidermal-cell microsomes". FEBS Lett. 187 (2): 314–320. doi:10.1016/0014-5793(85)81267-9.