Influenza non-structural protein
| Influenza non-structural protein (NS1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Flu_NS1 | ||||||||
| Pfam | PF00600 | ||||||||
| InterPro | IPR000256 | ||||||||
| |||||||||
Influenza non-structural protein (NS1) is a homodimeric RNA-binding protein found in influenza virus that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA.[1]
References
- ↑ Huang Y, Rios CB, Tejero R, Zimmerman DE, Krug RM, Montelione GT, Chien CY (1997). "A novel RNA-binding motif in influenza A virus non-structural protein 1". Nat. Struct. Biol. 4 (11): 891–895. doi:10.1038/nsb1197-891. PMID 9360601.
This article incorporates text from the public domain Pfam and InterPro IPR000256
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