Inositol-polyphosphate 5-phosphatase
| Inositol-polyphosphate 5-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.56 | ||||||||
| CAS number | 106283-14-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Inositol-polyphosphate 5-phosphatase (EC 3.1.3.56, type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP3/Ins(1,3,4,5)P4 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P3 5-phosphatase, D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase) is an enzyme with systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) D-myo-inositol 1,4,5-trisphosphate + H2O myo-inositol 1,4-bisphosphate + phosphate
- (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O 1D-myo-inositol 1,3,4-trisphosphate + phosphate
One mammalian isoform is known.
References
- ↑ Downes, C.P.; Mussat, M.C.; Michell, R.H. (1982). "The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane". Biochem. J. 203: 169–177. PMID 6285891.
- ↑ Erneux, C.; Lemos, M.; Verjans, B.; Vanderhaeghen, P.; Delvaux, A.; Dumont, J.E. (1989). "Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain". Eur. J. Biochem. 181: 317–322. doi:10.1111/j.1432-1033.1989.tb14726.x. PMID 2540972.
- ↑ Woscholski, R.; Parker, P.J. (2000). "Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates". In Cockcroft, S. Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. pp. 320–338.
- ↑ Verjans, B.; De Smedt, F.; Lecocq, R.; Vanweyenberg, V.; Moreau, C.; Erneux, C. (1994). "Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase". Biochem. J. 300: 85–90. PMID 8198557.
External links
- Inositol-polyphosphate 5-phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)