Kari Nadeau

Dr. Kari Nadeau
Nationality American
Fields Allergy / Immunology
Institutions Stanford University
Education

Haverford College, BS

Harvard Medical School, MD, PhD
Doctoral advisor Christopher T. Walsh
Known for Allergy Prevention & Treatment
Website
med.stanford.edu/profiles/kari-nadeau

Kari Nadeau is a physician-scientist focused on allergy and asthma treatment at Stanford University School of Medicine. She is the Naddisy Family Foundation Professor of Allergy[1] and the Director of the Sean N Parker Center for Allergy Research at Stanford.

Education

After graduating from Haverford College (summa cum laude) with a degree in biology,[2] Dr. Nadeau attended Harvard Medical School via the Medical Scientist Training Program (NIH), and received a PhD in Biological Chemistry and Molecular Pharmacology and an MD in 1995. She then performed an internship and residency in pediatrics at the Children’s Hospital Boston, Harvard Medical School. From 1998 to 2002, she worked in the field of biopharmaceuticals and led clinical research to obtain FDA approval for two biologics in the field of Autoimmunity and Oncology, respectively. From 2003-2006, Dr. Nadeau was a fellow in Asthma, Allergy and Immunology at the Stanford/UCSF program under Dr. Dale Umetsu. During this time, she also did a postdoctoral fellowship in human immune tolerance mechanisms in asthma and allergy.

Academic position

In 2006, Dr. Nadeau was appointed to the Stanford University School of Medicine with appointments in Pediatrics and Otolaryngology. She currently holds an endowed professorship under the Naddisy Family Foundation. Dr. Nadeau has served as a reviewer for NIH Study Sections, and a member of the American Lung Association Medical Board, CA. She serves on the Environmental Health Policy committee for the American Thoracic Society and is a Fellow in the American Academy of Allergy, Asthma and Immunology and is a member of ASCI (American Society of Clinical Investigation). Her laboratory focuses on the study of immunological mechanisms involved in the cause, diagnosis, and therapy for allergy and asthma.[3] In December, 2014 Sean Parker donated $24 million to Stanford to establish the Sean N. Parker Center for Allergy Research at Stanford University,[4] with Dr. Nadeau as the director.[5][6]

Media

Dr. Nadeau and her work have made a number of media appearances supporting food allergy awareness and research:

Research

Dr. Nadeau's laboratory is working on scientific investigations of immune tolerance. Areas of research include:

  1. Primary immune defects in tolerance - Gene silencing helps demonstrate the role of STAT5A and STAT5B in human immunology and signaling.,,[18][19][20]
  2. Environmental effects on tolerance - Ambient air pollution, specifically polycyclic aromatic hydrocarbons found in diesel exhaust have been demonstrated to affect FOXP3 gene expression via the aryl hydrocarbon receptor in regulatory T-cells.,[21][22]
  3. Immunomodulatory agents effect on tolerance - Studying the innumologic mechanisms of oral immunotherapy via the effects on Foxp3, IL-10, IFN, and IL-4.,[23][24]

Honors and awards

References

  1. ↑ "Dr. Kari Nadeau". Med.stanford.edu. Retrieved 2015-05-13.
  2. ↑ "The Allergy Buster" (PDF). Haverford College Magazine (Spring-Summer 2013): 30–32. Retrieved 6 May 2015.
  3. ↑ "The Nadeau Lab". Nadeaulab.stanford.edu. Retrieved 2015-05-13.
  4. ↑ "Sean Parker Center". Med.stanford.edu. Retrieved 2015-05-13.
  5. ↑ "Techcrunch". Techcrunch.com. Retrieved 3 May 2015.
  6. ↑ "Why Sean Parker Gave $24 Million To Build A Stanford Allergy Research Center". Forbes.com. Retrieved 3 May 2015.
  7. ↑ "The Allergy Buster". The New York Times. Retrieved 3 May 2015.
  8. ↑ "Katie Couric". The New York Times. Retrieved 3 May 2015.
  9. ↑ "Funding a Cure for Food Allergies". Cnn.com. Retrieved 3 May 2015.
  10. ↑ "The Doctor Trying To Solve The Mystery Of Food Allergies". Npr.org. Retrieved 3 May 2015.
  11. ↑ "Encouraging news for food allergy sufferers". Cbsnews.com. Retrieved 3 May 2015.
  12. ↑ "New Promise for People with Food Allergies". Huffingtonpost.com. Retrieved 3 May 2015.
  13. ↑ "The Human Rat in the Lab". Huffingtonpost.com. Retrieved 3 May 2015.
  14. ↑ "Allergy Free". Sixtyminutes.ninemsn.com.au. Retrieved 3 May 2015.
  15. ↑ "Food Allergy Treatments for Children Show Promise". Nbcnews.com. Retrieved 3 May 2015.
  16. ↑ "How Giving Children Foods They Are Allergic To Can Cure Them, And Other Provocative Approaches In Evolutionary Medicine". Forbes.com. Retrieved 6 May 2015.
  17. ↑ "Retraining the body to lift the life sentence of food allergies". Video.pbs.org. Retrieved 12 May 2015.
  18. ↑ Jenks JA, Seki S, Kanai T, Huang J, Morgan AA, Scalco RC, Nath R, Bucayu R, Wit JM, Al-Herz W, Ramadan D, Jorge AA, Bacchetta R, Hwa V, Rosenfeld R, Nadeau KC (2013). "Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells". Clin. Immunol. 148 (2): 227–36. doi:10.1016/j.clim.2013.04.014. PMC 4169138Freely accessible. PMID 23773921.
  19. ↑ Kanai T, Seki S, Jenks JA, Kohli A, Kawli T, Martin DP, Snyder M, Bacchetta R, Nadeau KC (2014). "Identification of STAT5A and STAT5B target genes in human T cells". PLoS ONE. 9 (1): e86790. doi:10.1371/journal.pone.0086790. PMC 3907443Freely accessible. PMID 24497979.
  20. ↑ Chen R, Giliani S, Lanzi G, Mias GI, Lonardi S, Dobbs K, Manis J, Im H, Gallagher JE, Phanstiel DH, Euskirchen G, Lacroute P, Bettinger K, Moratto D, Weinacht K, Montin D, Gallo E, Mangili G, Porta F, Notarangelo LD, Pedretti S, Al-Herz W, Alfahdli W, Comeau AM, Traister RS, Pai SY, Carella G, Facchetti F, Nadeau KC, Snyder M, Notarangelo LD (2013). "Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias". J. Allergy Clin. Immunol. 132 (3): 656–664.e17. doi:10.1016/j.jaci.2013.06.013. PMC 3759618Freely accessible. PMID 23830146.
  21. ↑ Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC (2013). "Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells". J Toxicol. 2013: 967029. doi:10.1155/2013/967029. PMC 3606805Freely accessible. PMID 23533402.
  22. ↑ Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC (2015). "Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells". Clin. Exp. Allergy. 45 (1): 238–48. doi:10.1111/cea.12377. PMC 4396982Freely accessible. PMID 25048800.
  23. ↑ Syed A, Garcia MA, Lyu SC, Bucayu R, Kohli A, Ishida S, Berglund JP, Tsai M, Maecker H, O'Riordan G, Galli SJ, Nadeau KC (2014). "Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)". J. Allergy Clin. Immunol. 133 (2): 500–10. doi:10.1016/j.jaci.2013.12.1037. PMC 4121175Freely accessible. PMID 24636474.
  24. ↑ Bégin P, Nadeau KC (2015). "Changes in peanut-specific T-cell clonotype with oral immunotherapy". J. Allergy Clin. Immunol. doi:10.1016/j.jaci.2015.03.010. PMID 25930192.
  25. ↑ "AAAAI Award Recipients". Aaaai.org\accessdate=2015-05-13.
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