LAD1

This article is about the gene. For the disease, see Leukocyte adhesion deficiency-1.
LAD1
Identifiers
Aliases LAD1, LadA, ladinin 1
External IDs MGI: 109343 HomoloGene: 4059 GeneCards: LAD1
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

3898

16763

Ensembl

ENSG00000159166

ENSMUSG00000041782

UniProt

O00515

P57016

RefSeq (mRNA)

NM_005558

NM_133664

RefSeq (protein)

NP_005549.2

NP_598425.2

Location (UCSC) Chr 1: 201.37 – 201.4 Mb Chr 1: 135.82 – 135.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Ladinin-1 is a protein that in humans is encoded by the LAD1 gene.[3][4][5]

The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Marinkovich MP, Taylor TB, Keene DR, Burgeson RE, Zone JJ (Jun 1996). "LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells". J Invest Dermatol. 106 (4): 734–8. doi:10.1111/1523-1747.ep12345782. PMID 8618013.
  4. Motoki K, Megahed M, LaForgia S, Uitto J (Apr 1997). "Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component". Genomics. 39 (3): 323–30. doi:10.1006/geno.1996.4507. PMID 9119369.
  5. 1 2 "Entrez Gene: LAD1 ladinin 1".

Further reading


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