LPCAT1

LPCAT1
Identifiers
Aliases	LPCAT1, lysophosphatidylcholine acyltransferase 1, AYTL2, PFAAP3, lpcat, AGPAT10, AGPAT9
External IDs	MGI: 2384812 HomoloGene: 9871 GeneCards: LPCAT1
EC number	2.3.1.67
Gene ontology Molecular function • 1-alkylglycerophosphocholine O-acyltransferase activity • metal ion binding • calcium ion binding • transferase activity • transferase activity, transferring acyl groups • 1-alkylglycerophosphocholine O-acetyltransferase activity • 1-alkenylglycerophosphocholine O-acyltransferase activity • 1-acylglycerophosphocholine O-acyltransferase activity • 1-acylglycerol-3-phosphate O-acyltransferase activity • 2-acylglycerol-3-phosphate O-acyltransferase activity Cellular component • integral component of membrane • Golgi apparatus • Golgi membrane • membrane • lipid particle • endoplasmic reticulum membrane • endoplasmic reticulum Biological process • phospholipid biosynthetic process • retina development in camera-type eye • lipid metabolic process • phosphatidylglycerol acyl-chain remodeling • positive regulation of protein catabolic process • phosphatidic acid biosynthetic process • triglyceride biosynthetic process • metabolic process • surfactant homeostasis • negative regulation of phosphatidylcholine biosynthetic process • phosphatidylcholine acyl-chain remodeling • phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79888	210992
Ensembl	n/a	ENSMUSG00000021608
UniProt	Q8NF37	Q3TFD2
RefSeq (mRNA)	NM_024830	NM_145376
RefSeq (protein)	NP_079106.3	NP_663351.3
Location (UCSC)	Chr 5: 1.46 – 1.52 Mb	Chr 13: 73.47 – 73.52 Mb
PubMed search	[1]	[2]
Wikidata

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Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene.^[3]

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".
4. Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.