Croup

This article is about the respiratory condition. For the part of a quadruped, see rump (animal). For the crop of a bird, see crop (anatomy). For the type of casino employee, see croupier.
Croup
laryngotracheitis, subglottic laryngitis, obstructive laryngitis, laryngotracheobronchitis

The steeple sign as seen on an AP neck X-ray of a child with croup
Specialty pediatrics
Symptoms "barky" cough, stridor, fever, stuffy nose[1]
Duration usually 1-2 days but can last up to 7 days[2]
Causes mostly viral[1]
Diagnostic method based on symptoms[3]
Differential diagnosis epiglottitis, airway foreign body, bacterial tracheitis[3][4]
Prevention influenza and diphtheria vaccination[4]
Medication steroids, epinephrine[3][4]
Frequency 15% of children at some point[3][4]
Deaths rare[1]

Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused by a virus.[1] The infection leads to swelling inside the wind pipe, which interferes with normal breathing and produces the classic symptoms of "barking" cough, stridor, and a hoarse voice. Fever and runny nose may also be present.[1] These symptoms may be mild, moderate, or severe.[2] Often it starts or is worse at night.[1][2] It normally lasts one to two days.[5]

Croup can be caused by a number of viruses including parainfluenza and influenza virus.[1] Rarely is it due to a bacterial infection.[4] Croup is typically diagnosed based on signs and symptoms after potentially more severe causes such as epiglottitis or an airway foreign body have been ruled out. Further investigations—such as blood tests, X-rays, and cultures—are usually not needed.[3]

Many cases of croup are preventable by immunization for influenza and diphtheria.[4] Croup is usually treated with a single dose of steroids by mouth.[1] In more severe cases inhaled epinephrine may also be used.[1][6] Hospitalization is required in one to five percent of cases.[7]

Croup is a relatively common condition that affects about 15% of children at some point.[3] It most commonly occurs between 6 months and 5 years of age but may rarely be seen in children as old as fifteen.[2][3][7] It is slightly more common in males than females. It occurs most often in autumn.[7] Before vaccination, croup was frequently caused by diphtheria and was often fatal.[4][8] This cause is now very rare in the Western world due to the success of the diphtheria vaccine.[9]

Signs and symptoms
Stridor
Inspiratory and expiratory stridor in a 13-month child with croup.
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Croup is characterized by a "barking" cough, stridor, hoarseness, and difficulty breathing which usually worsens at night.[1] The "barking" cough is often described as resembling the call of a seal or sea lion.[4] The stridor is worsened by agitation or crying, and if it can be heard at rest, it may indicate critical narrowing of the airways. As croup worsens, stridor may decrease considerably.[1]

Other symptoms include fever, coryza (symptoms typical of the common cold), and chest wall indrawing.[1][10] Drooling or a very sick appearance indicate other medical conditions.[10]

Causes

Croup is usually deemed to be due to a viral infection.[1][3] Others use the term more broadly, to include acute laryngotracheitis, spasmodic croup, laryngeal diphtheria, bacterial tracheitis, laryngotracheobronchitis, and laryngotracheobronchopneumonitis. The first two conditions involve a viral infection and are generally milder with respect to symptomatology; the last four are due to bacterial infection and are usually of greater severity.[4]

Viral

Viral croup or acute laryngotracheitis is caused by parainfluenza virus (a member of the paramyxovirus family), primarily types 1 and 2, in 75% of cases.[2] Other viral causes include influenza A and B, measles, adenovirus and respiratory syncytial virus (RSV).[4] Spasmodic croup is caused by the same group of viruses as acute laryngotracheitis, but lacks the usual signs of infection (such as fever, sore throat, and increased white blood cell count).[4] Treatment, and response to treatment, are also similar.[2]

Bacterial

Bacterial croup may be divided into laryngeal diphtheria, bacterial tracheitis, laryngotracheobronchitis, and laryngotracheobronchopneumonitis.[4] Laryngeal diphtheria is due to Corynebacterium diphtheriae while bacterial tracheitis, laryngotracheobronchitis, and laryngotracheobronchopneumonitis are usually due to a primary viral infection with secondary bacterial growth. The most common bacteria implicated are Staphylococcus aureus, Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis.[4]

Pathophysiology

The viral infection that causes croup leads to swelling of the larynx, trachea, and large bronchi[3] due to infiltration of white blood cells (especially histiocytes, lymphocytes, plasma cells, and neutrophils).[4] Swelling produces airway obstruction which, when significant, leads to dramatically increased work of breathing and the characteristic turbulent, noisy airflow known as stridor.[3]

Diagnosis

Westley score: Classification of croup severity[2][11]
Feature Number of points assigned for this feature
0 1 2 3 4 5
Chest wall
retraction		 None Mild Moderate Severe
Stridor None With
agitation		 At rest
Cyanosis None With
agitation		 At rest
Level of
consciousness		 Normal Disoriented
Air entry Normal Decreased Markedly decreased

Croup is a clinical diagnosis.[3] The first step is to exclude other obstructive conditions of the upper airway, especially epiglottitis, an airway foreign body, subglottic stenosis, angioedema, retropharyngeal abscess, and bacterial tracheitis.[3][4]

A frontal X-ray of the neck is not routinely performed,[3] but if it is done, it may show a characteristic narrowing of the trachea, called the steeple sign, because of the subglottic stenosis, which is similar to a steeple in shape. The steeple sign is suggestive of the diagnosis, but is absent in half of cases.[10]

Other investigations (such as blood tests and viral culture) are discouraged, as they may cause unnecessary agitation and thus worsen the stress on the compromised airway.[3] While viral cultures, obtained via nasopharyngeal aspiration, can be used to confirm the exact cause, these are usually restricted to research settings.[1] Bacterial infection should be considered if a person does not improve with standard treatment, at which point further investigations may be indicated.[4]

Severity

The most commonly used system for classifying the severity of croup is the Westley score. It is primarily used for research purposes rather than in clinical practice.[4] It is the sum of points assigned for five factors: level of consciousness, cyanosis, stridor, air entry, and retractions.[4] The points given for each factor is listed in the adjacent table, and the final score ranges from 0 to 17.[11]

85% of children presenting to the emergency department have mild disease; severe croup is rare (<1%).[2]

Prevention

Many cases of croup have been prevented by immunization for influenza and diphtheria.[4] At one time, croup referred to a diphtherial disease, but with vaccination, diphtheria is now rare in the developed world.[4]

Treatment

Children with croup are generally kept as calm as possible.[3] Steroids are given routinely, with epinephrine used in severe cases.[3] Children with oxygen saturations under 92% should receive oxygen,[4] and those with severe croup may be hospitalized for observation.[10] If oxygen is needed, "blow-by" administration (holding an oxygen source near the child's face) is recommended, as it causes less agitation than use of a mask.[4] With treatment, less than 0.2% of people require endotracheal intubation.[11]

Steroids

Corticosteroids, such as dexamethasone and budesonide, have been shown to improve outcomes in children with all severities of croup.[12] Significant relief is obtained as early as six hours after administration.[12] While effective when given orally, parenterally, or by inhalation, the oral route is preferred.[3] A single dose is usually all that is required, and is generally considered to be quite safe.[3] Dexamethasone at doses of 0.15, 0.3 and 0.6 mg/kg appear to be all equally effective.[13]

Epinephrine

Moderate to severe croup may be improved temporarily with nebulized epinephrine.[3] While epinephrine typically produces a reduction in croup severity within 10–30 minutes, the benefits last for only about 2 hours.[1][3] If the condition remains improved for 2–4 hours after treatment and no other complications arise, the child is typically discharged from the hospital.[1][3]

Other

While other treatments for croup have been studied, none have sufficient evidence to support their use. Inhalation of hot steam or humidified air is a traditional self-care treatment, but clinical studies have failed to show effectiveness[3][4] and currently it is rarely used.[14] The use of cough medicines, which usually contain dextromethorphan and/or guaifenesin, are also discouraged.[1] While breathing heliox (a mixture of helium and oxygen) to decrease the work of breathing has been used in the past, there is very little evidence to support its use.[15] Since croup is usually a viral disease, antibiotics are not used unless secondary bacterial infection is suspected.[1] In cases of possible secondary bacterial infection, the antibiotics vancomycin and cefotaxime are recommended.[4] In severe cases associated with influenza A or B, the antiviral neuraminidase inhibitors may be administered.[4]

Prognosis

Viral croup is usually a self-limited disease,[1] with half of cases going away in a day and 80% of cases in two days.[5] It can very rarely result in death from respiratory failure and/or cardiac arrest.[1] Symptoms usually improve within two days, but may last for up to seven days.[2] Other uncommon complications include bacterial tracheitis, pneumonia, and pulmonary edema.[2]

Epidemiology

Croup affects about 15% of children, and usually presents between the ages of 6 months and 5–6 years.[3][4] It accounts for about 5% of hospital admissions in this population.[2] In rare cases, it may occur in children as young as 3 months and as old as 15 years.[2] Males are affected 50% more frequently than are females, and there is an increased prevalence in autumn.[4]

History

The word croup comes from the Early Modern English verb croup, meaning "to cry hoarsely"; the name was first applied to the disease in Scotland and popularized in the 18th century.[16] Diphtheritic croup has been known since the time of Homer's Ancient Greece and it was not until 1826 that viral croup was differentiated from croup due to diphtheria by Bretonneau.[9][14] Viral croup was then called "faux-croup" by the French and often called "false croup" in English,[17][18] as "croup" or "true croup" then most often referred to the disease caused by the diphtheria bacterium.[19][20] False croup has also been known as pseudo croup or spasmodic croup.[21] Croup due to diphtheria has become nearly unknown in affluent countries in modern times due to the advent of effective immunization.[9][22]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Rajapaksa S, Starr M (May 2010). "Croup – assessment and management". Aust Fam Physician. 39 (5): 280–2. PMID 20485713.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Johnson D (2009). "Croup". Clin Evid (Online). 2009. PMC 2907784Freely accessible. PMID 19445760.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Everard ML (February 2009). "Acute bronchiolitis and croup". Pediatr. Clin. North Am. 56 (1): 119–33, x–xi. doi:10.1016/j.pcl.2008.10.007. PMID 19135584.
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Cherry JD (2008). "Clinical practice. Croup". N. Engl. J. Med. 358 (4): 384–91. doi:10.1056/NEJMcp072022. PMID 18216359.
  5. 1 2 Thompson, M; Vodicka, TA; Blair, PS; Buckley, DI; Heneghan, C; Hay, AD; TARGET Programme, Team (Dec 11, 2013). "Duration of symptoms of respiratory tract infections in children: systematic review.". BMJ (Clinical research ed.). 347: f7027. doi:10.1136/bmj.f7027. PMC 3898587Freely accessible. PMID 24335668.
  6. ↑ Bjornson, C; Russell, K; Vandermeer, B; Klassen, TP; Johnson, DW (10 October 2013). "Nebulized epinephrine for croup in children.". The Cochrane database of systematic reviews. 10: CD006619. doi:10.1002/14651858.CD006619.pub3. PMID 24114291.
  7. 1 2 3 Bjornson, CL; Johnson, DW (15 October 2013). "Croup in children.". CMAJ : Canadian Medical Association [Journal de l'Association medicale canadienne]. 185 (15): 1317–23. doi:10.1503/cmaj.121645. PMC 3796596Freely accessible. PMID 23939212.
  8. ↑ Steele, Volney (2005). Bleed, blister, and purge : a history of medicine on the American frontier. Missoula, Mont.: Mountain Press. p. 324. ISBN 978-0-87842-505-1.
  9. 1 2 3 Feigin, Ralph D. (2004). Textbook of pediatric infectious diseases. Philadelphia: Saunders. p. 252. ISBN 0-7216-9329-6.
  10. 1 2 3 4 "Diagnosis and Management of Croup" (PDF). BC Children's Hospital Division of Pediatric Emergency Medicine Clinical Practice Guidelines.
  11. 1 2 3 Klassen TP (December 1999). "Croup. A current perspective". Pediatr. Clin. North Am. 46 (6): 1167–78. doi:10.1016/S0031-3955(05)70180-2. PMID 10629679.
  12. 1 2 Russell KF, Liang Y, O'Gorman K, Johnson DW, Klassen TP (2011). "Glucocorticoids for croup". Cochrane Database Syst Rev. 1 (1): CD001955. doi:10.1002/14651858.CD001955.pub3. PMID 21249651.
  13. ↑ Port C (April 2009). "Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 4. Dose of dexamethasone in croup". Emerg Med J. 26 (4): 291–2. doi:10.1136/emj.2009.072090. PMID 19307398.
  14. 1 2 Marchessault V (November 2001). "Historical review of croup". Can J Infect Dis. 12 (6): 337–9. PMC 2094841Freely accessible. PMID 18159359.
  15. ↑ Vorwerk C, Coats T (2010). "Heliox for croup in children". Cochrane Database Syst Rev. 2 (2): CD006822. doi:10.1002/14651858.CD006822.pub2. PMID 20166089.
  16. ↑ Online Etymological Dictionary, croup. Accessed 2010-09-13.
  17. ↑ Cormack, John Rose (8 May 1875). "Meaning of the Terms Diphtheria, Croup, and Faux Croup". British Medical Journal. 1 (749): 606. doi:10.1136/bmj.1.749.606. PMC 2297755Freely accessible. PMID 20747853.
  18. ↑ Loving, Starling (5 October 1895). "Something concerning the diagnosis and treatment of false croup". JAMA: The Journal of the American Medical Association. XXV (14): 567–573. doi:10.1001/jama.1895.02430400011001d. Retrieved 16 April 2014.
  19. ↑ Bennett, James Risdon (8 May 1875). "True and False Croup". British Medical Journal. 1 (749): 606–607. doi:10.1136/bmj.1.749.606-a. PMC 2297754Freely accessible. PMID 20747854.
  20. ↑ Beard, George Miller (1875). Our Home Physician: A New and Popular Guide to the Art of Preserving Health and Treating Disease. New York: E. B. Treat. pp. 560–564. Retrieved 15 April 2014.
  21. ↑ Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (8 ed.). Elsevier Health Sciences. 2014. p. 762. ISBN 978-0-323-26373-3.
  22. ↑ Vanderpool, Patricia (December 2012). "Recognizing croup and stridor in children". American Nurse Today. 7 (12). Retrieved 15 April 2014.

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