Lipoyl amidotransferase

Lipoyl amidotransferase (EC 2.3.1.200, LipL (gene)) is an enzyme with systematic name (glycine cleavage system H)-N⁶-lipoyl-L-lysine:(lipoyl-carrier protein)-N⁶-L-lysine lipoyltransferase.^[1] This enzyme catalyses the following chemical reaction

[glycine cleavage system H]-N⁶-lipoyl-L-lysine + [lipoyl-carrier protein]

\rightleftharpoons

glycine cleavage system H + [lipoyl-carrier protein]-N⁶-lipoyl-L-lysine

In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid.

References

↑ Christensen, Q.H.; Hagar, J.A.; O'Riordan, M.X.; Cronan, J.E. (2011). "A complex lipoate utilization pathway in Listeria monocytogenes". J. Biol. Chem. 286: 31447–31456. doi:10.1074/jbc.m111.273607. PMID 21768091.

External links

Lipoyl amidotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase N-Acetylglutamate synthase Choline acetyltransferase Dihydrolipoyl transacetylase Acetyl-CoA C-acyltransferase Beta-galactoside transacetylase Chloramphenicol acetyltransferase N-acetyltransferase Serotonin N-acetyl transferase HGSNAT ARD1A Histone acetyltransferase P300/CBP NAT2 palmitoyltransferases: Carnitine O-palmitoyltransferase CPT1 CPT2 Serine C-palmitoyltransferase SPTLC1 SPTLC2 other: Acyltransferase like 2 Aminolevulinic acid synthase Beta-ketoacyl-ACP synthase Glyceronephosphate O-acyltransferase Lecithin—cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase 2-acylglycerol-3-phosphate O-acyltransferase ABHD5

2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase Peptidyl transferase Transglutaminase Tissue transglutaminase Keratinocyte transglutaminase Factor XIII

2.3.3: converted into alkyl on transfer	Citrate synthase ATP citrate lyase HMG-CoA synthase Malate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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