| Title | Director | Cast (Subject of documentary) | Genre | Notes |
| (500) Days of Summer | Marc Webb | Joseph Gordon-Levitt, Zooey Deschanel | Romantic comedy | Fox Searchlight Pictures |
| 12 Rounds | Renny Harlin | John Cena, Ashley Scott, Steve Harris, Aidan Gillen, Brian J. White, Taylor Cole | Action | Fox Atomic, WWE Studios |
| 17 Again | Burr Steers | Zac Efron, Leslie Mann, Thomas Lennon, Matthew Perry, Melora Hardin, Michelle Trachtenberg, Sterling Knight | Comedy, Teen | New Line Cinema |
| 2012 | Roland Emmerich | John Cusack, Amanda Peet, Danny Glover, Thandie Newton, Oliver Platt, Chiwetel Ejiofor, Woody Harrelson | Disaster | Columbia Pictures |
| 9 | Shane Acker | Elijah Wood, John C. Reilly, Jennifer Connelly, Christopher Plummer, Crispin Glover, Martin Landau | Animated film | Focus Features |
| Adam | Max Mayer | Hugh Dancy, Rose Byrne, Peter Gallagher, Amy Irving, Frankie Faison, Mark Linn-Baker, Karina Arroyave | Comedy-drama | Fox Searchlight Pictures |
| Adventureland | Greg Mottola | Jesse Eisenberg, Kristen Stewart, Martin Starr, Bill Hader, Kristen Wiig, Margarita Levieva, Ryan Reynolds | Comedy | Based on Adventureland; Miramax Films |
| After.Life | Agnieszka Wojtowicz-Vosloo | Christina Ricci, Liam Neeson, Justin Long, Celia Weston | Horror | Anchor Bay Entertainment |
| Alien Trespass | R. W. Goodwin | Eric McCormack, Jenni Baird, Dan Lauria, Robert Patrick | Comedy, Science fiction | Rangeland Productions |
| Aliens in the Attic | John Schultz | Robert Hoffman, Ashley Tisdale, Carter Jenkins, Austin Butler, Kevin Nealon, Doris Roberts | Science fiction | 20th Century Fox, Regency Enterprises |
| All About Steve | Phil Traill | Sandra Bullock, Bradley Cooper, Thomas Haden Church | Comedy | 20th Century Fox, Radar Pictures |
| Alvin and the Chipmunks: The Squeakquel | Betty Thomas | Jason Lee, David Cross, Zachary Levi, Justin Long, Matthew Gray Gubler, Jesse McCartney, Anna Faris, Christina Applegate, Amy Poehler | Family, Musical | 20th Century Fox
Preceded by Alvin and the Chipmunks |
| Amelia | Mira Nair | Hilary Swank, Richard Gere, Ewan McGregor | Biography, Drama | Fox Searchlight Pictures |
| American Violet | Tim Disney | Nicole Beharie, Tim Blake Nelson, Will Patton, Michael O'Keefe, Xzibit, Charles S. Dutton, Alfre Woodard | Drama | Samuel Goldwyn Films |
| Angels & Demons | Ron Howard | Tom Hanks, Ayelet Zurer, Ewan McGregor, Stellan Skarsgård, Armin Mueller-Stahl, Pierfrancesco Favino, Nikolaj Lie Kaas | Adventure, Mystery | Columbia Pictures. Based on the novel by Dan Brown |
| The Answer Man | John Hindman | Jeff Daniels, Lauren Graham, Lou Taylor Pucci, Kat Dennings, Olivia Thirlby | Romantic comedy | Magnolia Pictures |
| Arcadia Lost | Phedon Papamichael, Jr. | Nick Nolte, Haley Bennett, Carter Jenkins, Dato Bakhtadze, Lachlan Buchanan, James Ivory | Drama | Merchant Films |
| Armored | Nimród Antal | Matt Dillon, Jean Reno, Laurence Fishburne, Milo Ventimiglia, Skeet Ulrich, Columbus Short, Amaury Nolasco, Fred Ward | Action, Crime drama | Screen Gems |
| Assassination of a High School President | Brett Simon | Bruce Willis, Reece Thompson, Mischa Barton | Comedy | Yari Film Group |
| Astro Boy | David Bowers | Freddie Highmore, Nicolas Cage, Donald Sutherland, Nathan Lane, Bill Nighy, Eugene Levy, Kristen Bell | Animated film | Summit Entertainment, Imagi Animation Studios
Based on Astro Boy by Osamu Tezuka |
| Avatar | James Cameron | Sam Worthington, Zoe Saldana, Sigourney Weaver, Michelle Rodriguez, Stephen Lang, Laz Alonso, Giovanni Ribisi, Joel Moore, Wes Studi | Epic, Science fiction | Noted as a breakthrough in 3D viewing and stereoscopic filmmaking[1] 20th Century Fox |
| Away We Go | Sam Mendes | John Krasinski, Maya Rudolph, Jeff Daniels, Maggie Gyllenhaal, Allison Janney, Chris Messina, Catherine O'Hara, Paul Schneider, Jim Gaffigan, Melanie Lynskey, Josh Hamilton | Comedy-drama | Focus Features |
| The Bad Lieutenant: Port of Call New Orleans | Werner Herzog | Nicolas Cage, Eva Mendes, Val Kilmer, Xzibit | Crime drama | Millennium Films |
| Bandslam | Todd Graff | Aly Michalka, Vanessa Hudgens, Gaelan Connell, Scott Porter, Lisa Kudrow | Musical | Summit Entertainment, Walden Media |
| Battle for Terra | Aristomenis Tsirbas | Evan Rachel Wood, Brian Cox, James Garner, Chris Evans, Danny Glover, Amanda Peet, David Cross, Justin Long, Dennis Quaid, Luke Wilson | Science fiction, Animated | Lionsgate |
| Beyond a Reasonable Doubt | Peter Hyams | Michael Douglas, Jesse Metcalfe, Amber Tamblyn, Orlando Jones | Drama | RKO Pictures; based on Fritz Lang's '1956 film |
| Big Fan | Robert D. Siegel | Patton Oswalt, Kevin Corrigan, Michael Rapaport, Marcia Jean Kurtz | Drama | First Independent Pictures |
| The Blind Side | John Lee Hancock | Sandra Bullock, Kathy Bates, Tim McGraw, Ray McKinnon, Quinton Aaron | Drama | Warner Bros. Pictures, Alcon Entertainment
Based on The Blind Side: Evolution of a Game by Michael Lewis; Oscar for Bullock |
| Boogie Town | Chris Stokes | Marques Houston, Brenda Song | Dance | Awaiting release |
| The Boondock Saints II: All Saints Day | Troy Duffy | Sean Patrick Flanery, Norman Reedus, Clifton Collins, Jr., Julie Benz, Judd Nelson, Bob Marley, Brian Mahoney, David Ferry, David Della Rocco, Peter Fonda, Billy Connolly | Action | Apparition; preceded by The Boondock Saints (1999) |
| The Box | Richard Kelly | Cameron Diaz, James Marsden, Frank Langella, James Rebhorn, Holmes Osborne, Gillian Jacobs | Science fiction | Warner Bros. Pictures
Based on "Button, Button" by Richard Matheson |
| Bride Wars | Gary Winick | Kate Hudson, Anne Hathaway, Candice Bergen | Comedy | 20th Century Fox, Regency Enterprises |
| Brothers | Jim Sheridan | Tobey Maguire, Jake Gyllenhaal, Natalie Portman, Sam Shepard | War | Lionsgate
Based on Brothers (2004) |
| The Brothers Bloom | Rian Johnson | Adrien Brody, Mark Ruffalo, Rachel Weisz, Rinko Kikuchi, Robbie Coltrane, Maximilian Schell | Comedy, Crime | Summit Entertainment |
| Brothers at War | Jake Rademacher | Soldiers in the Iraq War | Documentary | Samuel Goldwyn Films |
| Brüno | Larry Charles | Sacha Baron Cohen | Mockumentary | Universal Pictures |
| C Me Dance | Greg Robbins | Greg Robbins, Christina DeMarco, Laura Romeo, Peter Kent | Thriller | Freestyle Releasing |
| Capitalism: A Love Story | Michael Moore | The financial crisis of 2007–2010 | Documentary | Overture Films |
| Carriers | Alex Pastor, David Pastor | Lou Taylor Pucci, Chris Pine, Piper Perabo, Emily VanCamp, Christopher Meloni | Horror | Paramount Vantage |
| The Chaos Experiment | Philippe Martinez | Val Kilmer, Armand Assante, Eric Roberts | Drama | |
| A Christmas Carol | Robert Zemeckis | Jim Carrey, Gary Oldman, Cary Elwes, Colin Firth | Animation | Based on A Christmas Carol by Charles Dickens |
| Cirque du Freak: The Vampire's Assistant | Paul Weitz | John C. Reilly, Ken Watanabe, Josh Hutcherson, Chris Massoglia, Michael Cerveris, Ray Stevenson, Patrick Fugit, Willem Dafoe, Salma Hayek | Fantasy | Universal Pictures
Based on The Saga of Darren Shan by Darren Shan |
| Cloudy with a Chance of Meatballs | Phil Lord, Chris Miller | Bill Hader, Anna Faris, James Caan, Andy Samberg, Bruce Campbell, Mr. T, Bobb'e J. Thompson, Benjamin Bratt, Neil Patrick Harris, Al Roker, Lauren Graham, Will Forte | Animated | Columbia Pictures, Sony Pictures Animation
Based on Cloudy with a Chance of Meatballs by Judi Barrett and Ron Barrett |
| Cold Souls | Sophie Barthes | Paul Giamatti, Emily Watson, David Strathairn, Dina Korzun | Comedy | Samuel Goldwyn Films |
| The Collector | Marcus Dunstan | Josh Stewart, Michael Reilly Burke, Andrea Roth, Juan Fernández | Horror | Freestyle Releasing |
| Confessions of a Shopaholic | P. J. Hogan | Isla Fisher, Hugh Dancy, Joan Cusack, John Goodman, John Lithgow, Kristin Scott Thomas, Leslie Bibb | Romantic comedy | Touchstone Pictures. Based on the Shopaholic series by Sophie Kinsella |
| Coraline | Henry Selick | Dakota Fanning, Teri Hatcher, Ian McShane, Jennifer Saunders, Dawn French | Animated | Focus Features; based on Coraline by Neil Gaiman |
| Couples Retreat | Peter Billingsley | Vince Vaughn, Jon Favreau, Jason Bateman, Faizon Love, Kristin Davis, Malin Åkerman, Kristen Bell, Kali Hawk, Jean Reno | Comedy | Universal Pictures |
| The Cove | Louie Psihoyos | The annual killing of dolphins at Taiji, Wakayama | Documentary | Lionsgate |
| Crank: High Voltage | Mark Neveldine, Brian Taylor | Jason Statham, Amy Smart, Clifton Collins, Jr., Efren Ramirez, Dwight Yoakam, Reno Wilson, Bai Ling, David Carradine | Action | Lionsgate, Lakeshore Entertainment; preceded by Crank (2006) |
| Crazy Heart | Scott Cooper | Jeff Bridges, Maggie Gyllenhaal, Robert Duvall, Colin Farrell | Drama, Musical | Fox Searchlight Pictures; Oscar for Bridges |
| The Cross | Matthew Crouch | Arthur Blessitt | Documentary | Gener8Xion Entertainment |
| Crossing Over | Wayne Kramer | Harrison Ford, Sean Penn, Jim Sturgess, Ashley Judd, Alice Eve, Alice Braga, Cliff Curtis, Summer Bishil, Ray Liotta | Drama | The Weinstein Company |
| Dance Flick | Damien Dante Wayans | Shoshana Bush, Damon Wayans, Jr. | Dance, Parody | Paramount Pictures, MTV Films |
| Did You Hear About the Morgans? | Marc Lawrence | Hugh Grant, Sarah Jessica Parker, Sam Elliott, Mary Steenburgen, Elisabeth Moss, Wilford Brimley, Michael Kelly | Comedy | Columbia Pictures |
| District 9 | Neill Blomkamp | Sharlto Copley, Jason Cope, David James | Science fiction | TriStar Pictures |
| Drag Me to Hell | Sam Raimi | Alison Lohman, Justin Long, Lorna Raver, Dileep Rao, David Paymer, Adriana Barraza | Horror | Universal Pictures |
| Dragonball Evolution | James Wong | Justin Chatwin, Emmy Rossum, Joon Park, Chow Yun-fat, James Marsters, Eriko Tamura, Jamie Chung, Randall Duk Kim | Action, Fantasy | 20th Century Fox
Based on the Dragon Ball franchise from Akira Toriyama |
| Duplicity | Tony Gilroy | Julia Roberts, Clive Owen, Tom Wilkinson, Paul Giamatti | Crime | Universal Pictures |
| Echelon Conspiracy | Greg Marcks | Shane West, Edward Burns, Ving Rhames, Jonathan Pryce, Tamara Feldman | Action | After Dark Films |
| Every Little Step | James D. Stern, Adam Del Deo | The casting of the 2006 Broadway revival of A Chorus Line | Documentary | Sony Picture Classics |
| Everybody's Fine | Nick Jones | Robert De Niro, Drew Barrymore, Kate Beckinsale, Sam Rockwell | Drama | Miramax Films
Based on Everybody's Fine |
| Extract | Mike Judge | Jason Bateman, Mila Kunis, Kristen Wiig, J. K. Simmons, Ben Affleck | Comedy | Miramax Films |
| Fame | Kevin Tancharoen | Debbie Allen, Charles S. Dutton, Kelsey Grammer, Megan Mullally, Bebe Neuwirth, Asher Book, Kristy Flores, Paul Iacono, Paul McGill, Naturi Naughton, Kay Panabaker, Kherington Payne, Collins Pennie, Walter Perez, Anna Maria Perez de Taglé | Drama, Musical | MGM; based on Fame |
| Fantastic Mr. Fox | Wes Anderson | George Clooney, Meryl Streep, Cate Blanchett, Anjelica Huston | Animated film | 20th Century Fox; based on Fantastic Mr. Fox by Roald Dahl |
| Fast & Furious | Justin Lin | Vin Diesel, Paul Walker, Michelle Rodriguez, Jordana Brewster | Action | Universal Pictures; preceded by The Fast and the Furious: Tokyo Drift (2006) |
| Fighting | Dito Montiel | Channing Tatum, Terrence Howard | Action | Rogue Pictures |
| The Final Destination | David R. Ellis | Bobby Campo, Shantel VanSanten, Haley Webb, Nick Zano, Mykelti Williamson | Horror | New Line Cinema
Preceded by Final Destination 3 (2006) |
| Fired Up! | Will Gluck | Nick D'Agosto, Eric Christian Olsen, Sarah Roemer, AnnaLynne McCord, Molly Sims, John Michael Higgins | Comedy, Teen | Screen Gems |
| Food, Inc. | Robert Kenner | Agricultural food production in United States | Documentary | Magnolia Pictures, Participant Media, River Road Entertainment |
| Fragments | Rowan Woods | Kate Beckinsale, Dakota Fanning, Guy Pearce, Josh Hutcherson, Forest Whitaker, Jennifer Hudson, Jackie Earle Haley, Jeanne Tripplehorn, Embeth Davidtz | Drama | Based on Winged Creatures by Roy Freirich; titled Winged Creatures internationally. Direct-to-DVD |
| Friday the 13th | Marcus Nispel | Jared Padalecki, Danielle Panabaker, Aaron Yoo, Amanda Righetti | Horror | New Line Cinema, Paramount Pictures; preceded by Freddy vs. Jason (2003) |
| Funny People | Judd Apatow | Adam Sandler, Seth Rogen, Leslie Mann, Eric Bana, Jonah Hill, RZA, Jason Schwartzman | Comedy drama | Universal Pictures, Columbia Pictures |
| G-Force | Hoyt Yeatman | Bill Nighy, Will Arnett, Zach Galifianakis, Nicolas Cage, Sam Rockwell, Jon Favreau, Penélope Cruz, Steve Buscemi, Tracy Morgan | Family, Live-action/animated film | Walt Disney Pictures |
| G.I. Joe: The Rise of Cobra | Stephen Sommers | Dennis Quaid, Channing Tatum, Marlon Wayans, Saïd Taghmaoui, Jonathan Pryce, Rachel Nichols, Sienna Miller, Lee Byung-hun, Joseph Gordon-Levitt, Christopher Eccleston, Adewale Akinnuoye-Agbaje | Action, Adventure | Paramount Pictures, Spyglass Entertainment. Based on the G.I. Joe: A Real American Hero franchise |
| Gallowwalker | Andrew Goth | Wesley Snipes, Riley Smith, Patrick Bergin | Horror, Western | Awaiting release |
| Gamer | Mark Neveldine, Brian Taylor | Gerard Butler, Michael C. Hall, Chris "Ludacris" Bridges, Kyra Sedgwick, Amber Valletta, Logan Lerman, Terry Crews | Action, Science fiction | Lionsgate, Lakeshore Entertainment |
| Gentlemen Broncos | Jared Hess | Michael Angarano, Jemaine Clement, Sam Rockwell, Jennifer Coolidge | Comedy | Fox Searchlight Pictures |
| Ghosts of Girlfriends Past | Mark Waters | Matthew McConaughey, Jennifer Garner, Michael Douglas, Breckin Meyer, Lacey Chabert, Emma Stone, Anne Archer, Robert Forster, Amanda Walsh, Noureen DeWulf | Fantasy, Romantic comedy | New Line Cinema. Based on A Christmas Carol by Charles Dickens |
| Gigantic | Matt Aselton | Paul Dano, Zooey Deschanel, Ed Asner, Jane Alexander, John Goodman | Comedy | First Independent Pictures |
| The Girlfriend Experience | Steven Soderbergh | Sasha Grey | Drama | Magnolia Pictures |
| The Goods: Live Hard, Sell Hard | Neal Brennan | Jeremy Piven, Ving Rhames, James Brolin, David Koechner, Kathryn Hahn, Ed Helms, Jordana Spiro, Craig Robinson, Ken Jeong, Rob Riggle, Noureen DeWulf, Tony Hale, Joey Kern, Alan Thicke, Will Ferrell | Comedy | Paramount Vantage |
| The Great Buck Howard | Sean McGinly | John Malkovich, Colin Hanks, Emily Blunt, Steve Zahn, Tom Hanks | Comedy-drama | Magnolia Pictures |
| The Grudge 3 | Toby Wilkins | Johanna Braddy, Gil McKinney, Shawnee Smith, Emi Ikehata, Jadie Hobson, Beau Mirchoff, Marina Sirtis, Matthew Knight | Horror–Thriller | Stage 6 Films, Sony(USA), Columbia Pictures |
| Halloween II | Rob Zombie | Malcolm McDowell, Sheri Moon Zombie, Scout Taylor-Compton, Tyler Mane, Brad Dourif, Danielle Harris | Horror | Dimension Films
Preceded by Halloween (2007) |
| The Hangover | Todd Phillips | Bradley Cooper, Ed Helms, Zach Galifianakis, Heather Graham, Justin Bartha | Comedy | Warner Bros., Legendary Pictures |
| Hannah Montana: The Movie | Peter Chelsom | Miley Cyrus, Emily Osment, Jason Earles, Mitchel Musso, Moisés Arias, Melora Hardin, Vanessa Williams, Billy Ray Cyrus, Lucas Till | Family, Musical | Walt Disney Pictures. Based on Hannah Montana |
| Harry Potter and the Half-Blood Prince | David Yates | Daniel Radcliffe, Rupert Grint, Emma Watson, Jim Broadbent, Helena Bonham Carter, Robbie Coltrane, Warwick Davis, Michael Gambon, Alan Rickman, Maggie Smith, Timothy Spall, David Thewlis, Julie Walters | Family, Fantasy | Warner Bros. Pictures. Based on the novel of the same name by J. K. Rowling
Preceded by Harry Potter and the Order of the Phoenix (2007) |
| The Haunting in Connecticut | Peter Cornwell | Virginia Madsen, Kyle Gallner, Martin Donovan, Elias Koteas, Amanda Crew | Horror | Lionsgate, Gold Circle Films |
| He's Just Not That Into You | Ken Kwapis | Ben Affleck, Jennifer Aniston, Drew Barrymore, Jennifer Connelly, Kevin Connelly, Bradley Cooper, Ginnifer Goodwin, Scarlett Johansson, Justin Long | Romantic comedy | New Line Cinema. Based on the self-help book by Greg Behrendt and Liz Tuccillo |
| The Hole | Joe Dante | Teri Polo, Chris Massoglia, Haley Bennett | Fantasy, Thriller | Bold Films |
| Homecoming | Morgan J. Freeman | Mischa Barton, Matt Long, Jessica Stroup | Horror | Animus Films |
| Horrorween | Joe Estevez | Chuck Lamb, Ed Meyer, Tila Tequila | Comedy horror | |
| Horsemen | Jonas Åkerlund | Dennis Quaid, Zhang Ziyi, Clifton Collins, Jr., Patrick Fugit, Peter Stormare | Crime drama | Lionsgate, Mandate Pictures |
| Hotel for Dogs | Thor Freudenthal | Emma Roberts, Jake T. Austin, Kyla Pratt, Don Cheadle, Lisa Kudrow, Kevin Dillon | Comedy, Family | DreamWorks Pictures, Nickelodeon Movies. Based on Hotel for Dogs by Lois Duncan |
| Humpday | Lynn Shelton | Mark Duplass, Joshua Leonard, Alycia Delmore | Comedy | Magnolia Pictures |
| I Can Do Bad All By Myself | Tyler Perry | Tyler Perry, Taraji P. Henson, Mary J. Blige, Adam Rodríguez, Brian White, Gladys Knight, Pastor Marvin Winans | Comedy, Drama | Lionsgate
Preceded by Madea Goes to Jail |
| I Hate Valentine's Day | Nia Vardalos | Nia Vardalos, John Corbett | Romantic comedy | Blue Star Entertainment |
| I Hope They Serve Beer in Hell | Bob Gosse | Matt Czuchry, Jesse Bradford, Geoff Stults | Comedy | Based on I Hope They Serve Beer in Hell by Tucker Max |
| The Hurt Locker | Kathryn Bigelow | Jeremy Renner, Anthony Mackie, Brian Geraghty, Evangeline Lilly, Ralph Fiennes, David Morse, Guy Pearce | War | Summit Entertainment; Oscar for Bigelow |
| I Love You, Beth Cooper | Chris Columbus | Hayden Panettiere, Paul Rust, Jack Carpenter, Lauren London, Lauren Storm, Alan Ruck, Cynthia Stevenson | Comedy, Teen | 20th Century Fox. Based on I Love You, Beth Cooper by Larry Doyle |
| I Love You, Man | John Hamburg | Paul Rudd, Jason Segel | Comedy | Paramount Pictures |
| Ice Age: Dawn of the Dinosaurs | Carlos Saldanha, Mike Thurmeier | Ray Romano, John Leguizamo, Denis Leary, Queen Latifah, Josh Peck, Simon Pegg | Family | Animated film. 20th Century Fox. Preceded by Ice Age: The Meltdown (2006) |
| Imagine That | Karey Kirkpatrick | Eddie Murphy | Comedy | Paramount Pictures, Nickelodeon Movies |
| The Imaginarium of Doctor Parnassus | Terry Gilliam | Heath Ledger, Christopher Plummer, Lily Cole, Verne Troyer, Andrew Garfield, Tom Waits, Johnny Depp, Jude Law, Colin Farrell | Adventure, Comedy | Sony Pictures Classics |
| The Informant! | Steven Soderbergh | Matt Damon, Scott Bakula, Joel McHale, Melanie Lynskey | Black comedy, Biography | Warner Bros. Pictures
Based on The Informant by Kurt Eichenwald |
| The Informers | Gregor Jordan | Billy Bob Thornton, Kim Basinger, Winona Ryder, Mickey Rourke, Jon Foster, Amber Heard, Rhys Ifans, Chris Isaak, Austin Nichols, Lou Taylor Pucci, Mel Raido, Brad Renfro | Drama | Based on The Informers by Bret Easton Ellis |
| Inglourious Basterds | Quentin Tarantino | Brad Pitt, Mélanie Laurent, Christoph Waltz, Daniel Brühl, Diane Kruger, Michael Fassbender, Eli Roth, Til Schweiger | War, Science fiction | Universal Pictures, The Weinstein Company |
| The International | Tom Tykwer | Clive Owen, Naomi Watts | Action, Thriller | Columbia Pictures |
| Invictus | Clint Eastwood | Morgan Freeman, Matt Damon | Biography, Drama | Warner Bros. Pictures
Based on Playing the Enemy: Nelson Mandela and the Game That Changed a Nation by John Carlin |
| An Invisible Sign | Marilyn Agrelo | Jessica Alba, J. K. Simmons, Chris Messina | Drama | Awaiting release |
| The Invention of Lying | Ricky Gervais, Matthew Robinson | Ricky Gervais, Jennifer Garner, Jonah Hill, Louis C.K., Rob Lowe, Tina Fey, Christopher Guest | Comedy, Science fiction | Warner Bros. Pictures |
| It Might Get Loud | Davis Guggenheim | The careers and styles of Jimmy Page, The Edge, and Jack White | Documentary | Sony Pictures Classics |
| It's Complicated | Nancy Meyers | Robert Adamson, Blanchard Ryan, Meryl Streep, Steve Martin, Alec Baldwin | Romantic comedy | Universal Pictures |
| Janky Promoters | Marcus Raboy | Ice Cube, Mike Epps, Young Jeezy | Comedy | Third Rail Releasing |
| Jennifer's Body | Karyn Kusama | Megan Fox, Amanda Seyfried, Johnny Simmons, J. K. Simmons, Amy Sedaris, Adam Brody | Comedy horror, Teen | 20th Century Fox, Fox Atomic |
| Jonas Brothers: The 3D Concert Experience | Bruce Hendricks | Jonas Brothers, Demi Lovato, Taylor Swift, Christa B. Allen | Concert | Walt Disney Pictures |
| Julie & Julia | Nora Ephron | Meryl Streep, Amy Adams, Stanley Tucci, Chris Messina, Linda Emond | Biography, Romantic comedy | Columbia Pictures. Based on My Life in France by Alex Prud'homme and Julie & Julia: 365 Days, 524 Recipes, 1 Tiny Apartment Kitchen by Julie Powell |
| Knowing | Alex Proyas | Nicolas Cage | Science fiction | Summit Entertainment |
| Labor Pains | Lara Shapiro | Lindsay Lohan, Luke Kirby, Cheryl Hines, Chris Parnell, Bridgit Mendler, Kevin Covais | Romantic comedy, Romantic | First Look Studios |
| Laid to Rest | Robert Green Hall | Bobbi Sue Luther, Kevin Gage, Sean Whalen, Johnathon Schaech, Thomas Dekker, Nick Principe, Richard Lynch, Lena Headey | Horror | Direct-to-DVD, Dry County Films, Anchor Bay Entertainment |
| Land of the Lost | Brad Silberling | Will Ferrell, Danny McBride, Anna Friel, Jorma Taccone | Adventure | Universal Pictures, Relativity Media; based on the TV series of the same name |
| The Last House on the Left | Dennis Iliadis | Garret Dillahunt, Rhys Coiro, Martha MacIsaac, Riki Lindhome, Tony Goldwyn, Monica Potter, Spencer Treat Clark, Sara Paxton | Horror | Rogue Pictures; based on The Last House on the Left |
| Law Abiding Citizen | F. Gary Gray | Gerard Butler, Jamie Foxx, Colm Meaney, Bruce McGill, Regina Hall, Viola Davis | Thriller | Overture Films |
| Life During Wartime | Todd Solondz | Ally Sheedy, Gaby Hoffmann | Comedy-drama | Preceded by Happiness |
| The Limits of Control | Jim Jarmusch | Isaach de Bankolé, Bill Murray, Tilda Swinton, Gael García Bernal | Crime drama | Focus Features |
| Love Happens | Brandon Camp | Aaron Eckhart, Jennifer Aniston | Romance | Universal Pictures |
| Love N' Dancing | Robert Iscove | Amy Smart, Tom Malloy, Billy Zane | Dance, Romance | Screen Media Films |
| The Lovely Bones | Peter Jackson | Saoirse Ronan, Rachel Weisz, Mark Wahlberg, Stanley Tucci | Drama | DreamWorks Pictures
Based on The Lovely Bones by Alice Sebold |
| Lymelife | Derick Martini | Alec Baldwin, Emma Roberts, Rory Culkin, Kieran Culkin, Jill Hennessy, Timothy Hutton, Cynthia Nixon | Drama | Screen Media Films |
| Madea Goes to Jail | Tyler Perry | Tyler Perry, Sofía Vergara, Vanessa Ferlito, Derek Luke, Keshia Knight Pulliam, David Mann, Ion Overman, RonReaco Lee, Viola Davis | Comedy, Drama | Lionsgate; based on Madea Goes to Jail |
| The Maiden Heist | Peter Hewitt | Christopher Walken, Morgan Freeman, William H. Macy | Comedy, Crime | Yari Film Group |
| Management | Stephen Belber | Steve Zahn, Jennifer Aniston, Woody Harrelson, Fred Ward | Comedy | Samuel Goldwyn Films |
| Me and Orson Welles | Richard Linklater | Ben Chaplin, Claire Danes, Zac Efron, Zoe Kazan, Eddie Marsan, Christian McKay, Kelly Reilly, James Tupper | Biography, Drama | Warner Bros. |
| The Men Who Stare at Goats | Grant Heslov | Ewan McGregor, George Clooney, Kevin Spacey, Jeff Bridges | Comedy | Overture Films; based on The Men Who Stare at Goats by Jon Ronson |
| The Merry Gentleman | Michael Keaton | Michael Keaton, Kelly Macdonald | Dramedy | |
| The Messenger | Oren Moverman | Ben Foster, Woody Harrelson, Samantha Morton, Jena Malone, Steve Buscemi | Drama | Oscilloscope Pictures |
| Michael Jackson's This Is It | Kenny Ortega | Michael Jackson's final concert, canceled after his death | Documentary | Columbia Pictures |
| Miss March | Zach Cregger, Trevor Moore | Zach Cregger, Trevor Moore, Raquel Alessi, Molly Stanton, Craig Robinson | Comedy | Fox Searchlight Pictures |
| Monsters vs. Aliens | Rob Letterman, Conrad Vernon | Reese Witherspoon, Seth Rogen, Hugh Laurie, Rainn Wilson, Kiefer Sutherland, Will Arnett, Stephen Colbert, Paul Rudd | Animated film | DreamWorks Animation |
| Motherhood | Katherine Dieckmann | Uma Thurman, Minnie Driver, Anthony Edwards | Comedy | |
| My Bloody Valentine 3D | Patrick Lussier | Jensen Ackles, Jaime King, Kerr Smith | Horror | Lionsgate; based on My Bloody Valentine |
| My Life in Ruins | Donald Petrie | Nia Vardalos, Richard Dreyfuss | Romantic comedy | Fox Searchlight Pictures |
| My Sister's Keeper | Nick Cassavetes | Cameron Diaz, Alec Baldwin, Abigail Breslin, Sofia Vassilieva, Joan Cusack, Thomas Dekker, Jason Patric | Drama | New Line Cinema; based on My Sister's Keeper by Jodi Picoult |
| My One and Only | Richard Loncraine | Renée Zellweger, Chris Noth, Kevin Bacon | Comedy | |
| New in Town | Jonas Elmer | Renée Zellweger, Harry Connick, Jr. | Romantic comedy | Lionsgate, Gold Circle Films |
| New Moon | Chris Weitz | Kristen Stewart, Robert Pattinson, Taylor Lautner | Fantasy, Romance | Based on New Moon by Stephenie Meyer
Preceded by Twilight (2008) |
| New York, I Love You | 10 directors | Bradley Cooper, Chris Cooper, Shia LaBeouf, Orlando Bloom, Andy García, Natalie Portman, Rachel Bilson, Julie Christie, James Caan | Anthology, Romance | Vivendi Entertainment |
| Next Day Air | Benny Boom | Donald Faison, Mike Epps, Wood Harris, Omari Hardwick, Darius McCrary, Yasmin Deliz, Mos Def | Comedy, Crime | Summit Entertainment |
| Night at the Museum: Battle of the Smithsonian | Shawn Levy | Ben Stiller, Dick Van Dyke, Robin Williams, Amy Adams, Hank Azaria, Owen Wilson, Steve Coogan, Jonah Hill, Ricky Gervais | Adventure, Family | 20th Century Fox; preceded by Night at the Museum |
| Nine | Rob Marshall | Daniel Day-Lewis, Marion Cotillard, Nicole Kidman, Penélope Cruz, Kate Hudson, Judi Dench, Fergie, Sophia Loren | Musical | The Weinstein Company |
| Ninja Assassin | James McTeigue | Rain, Naomie Harris, Rick Yune, Ben Miles, Sho Kosugi, Sung Kang | Action, Martial arts | Warner Bros., Legendary Pictures, Dark Castle Entertainment |
| Not Easily Broken | Bill Duke | Morris Chestnut, Taraji P. Henson, Kevin Hart, Eddie Cibrian, Jenifer Lewis | Drama | Screen Gems; based on Not Easily Broken by T. D. Jakes |
| Not Forgotten | Dror Soref | Simon Baker, Paz Vega | Thriller | |
| Notorious | George Tillman, Jr. | Jamal Woolard, Derek Luke, Angela Bassett, Anthony Mackie, Naturi Naughton | Bio-pic, Drama | Fox Searchlight Pictures |
| Observe and Report | Jody Hill | Seth Rogen, Anna Faris, Michael Peña, Ray Liotta | Black comedy | Warner Bros. Pictures, Legendary Pictures |
| Obsessed | Steve Shill | Idris Elba, Beyoncé Knowles, Ali Larter | Thriller | Screen Gems |
| Old Dogs | Walt Becker | John Travolta, Robin Williams, Kelly Preston, Seth Green, Ella Bleu Travolta, Conner Rayburn, Matt Dillon, Rita Wilson, Dax Shepard, Bernie Mac, Luis Guzmán, Justin Long | Comedy, Family | Walt Disney Pictures |
| Opie Gets Laid | James Ricardo | April Wade, Ute Werner, Jesselynn Desmond, James Ricardo, Gina DeVettori | Comedy | Vivendi Entertainment |
| Orphan | Jaume Collet-Serra | Vera Farmiga, Peter Sarsgaard, Isabelle Fuhrman, CCH Pounder, Jimmy Bennett | Horror | Warner Bros. Pictures, Dark Castle Entertainment |
| Pandorum | Christian Alvart | Dennis Quaid, Ben Foster | Horror, Science fiction | Overture Films |
| Paper Heart | Nicholas Jasenovec | Charlyne Yi, Michael Cera | Mockumentary | Overture Films, Alliance Films |
| Paul Blart: Mall Cop | Steve Carr | Kevin James, Jayma Mays, Keir O'Donnell, Bobby Cannavale, Stephen Rannazzisi, Shirley Knight | Comedy | Columbia Pictures |
| A Perfect Getaway | David Twohy | Timothy Olyphant, Milla Jovovich, Kiele Sanchez, Steve Zahn, Marley Shelton, Chris Hemsworth | Thriller | Rogue Pictures, Alliance Films |
| Phoebe in Wonderland | Daniel Barnz | Felicity Huffman, Patricia Clarkson, Elle Fanning, Campbell Scott, Bill Pullman | Fantasy | Silverwood Films |
| The Pink Panther 2 | Harald Zwart | Steve Martin, Jean Reno, Alfred Molina, Emily Mortimer, Aishwarya Rai | Comedy | Preceded by The Pink Panther (2006) |
| Planet 51 | Jorge Blanco | Dwayne Johnson, Jessica Biel, Justin Long, Gary Oldman, Seann William Scott, John Cleese | Science fiction | TriStar Pictures |
| Post Grad | Vicky Jenson | Alexis Bledel, Zach Gilford, Rodrigo Santoro, Jane Lynch, Carol Burnett, Michael Keaton | Romantic comedy | 20th Century Fox, Fox Atomic |
| Powder Blue | Timothy Linh Bui | Jessica Biel, Ray Liotta, Eddie Redmayne, Forest Whitaker, Kris Kristofferson, Lisa Kudrow, Patrick Swayze | Drama | Image Entertainment |
| Precious | Lee Daniels | Mo'Nique, Paula Patton, Mariah Carey, Lenny Kravitz, Sherri Shepherd, Gabourey Sidibe | Drama | Lionsgate; based on Push by Sapphire
winner of the Grand Jury Prize: Dramatic |
| The Princess and the Frog | Ron Clements, John Musker | Anika Noni Rose, Oprah Winfrey, Bruno Campos, Keith David, Michael-Leon Wooley, Jennifer Cody, Jim Cummings, John Goodman | Animation, Family | Walt Disney Pictures |
| The Private Lives of Pippa Lee | Rebecca Miller | Robin Wright Penn, Alan Arkin, Maria Bello, Monica Bellucci, Blake Lively, Julianne Moore, Keanu Reeves, Winona Ryder | Drama | Screen Media Films |
| The Proposal | Anne Fletcher | Sandra Bullock, Ryan Reynolds, Mary Steenburgen, Craig T. Nelson, Betty White | Romantic comedy | Touchstone Pictures |
| Public Enemies | Michael Mann | Johnny Depp, Christian Bale, Marion Cotillard, Channing Tatum, David Wenham, Stephen Graham, Giovanni Ribisi, Stephen Dorff, Billy Crudup | Crime drama, Biography | Universal Pictures |
| Push | Paul McGuigan | Chris Evans, Dakota Fanning, Camilla Belle, Djimon Hounsou | Science fiction | Summit Entertainment |
| Quantum Quest: A Cassini Space Odyssey | Harry Kloor, Dan St. Pierre | Chris Pine, Amanda Peet, Samuel L. Jackson | Animation | Awaiting release |
| Race to Witch Mountain | Andy Fickman | Dwayne Johnson, AnnaSophia Robb, Carla Gugino, Garry Marshall, Ciarán Hinds, Alexander Ludwig, Tom Everett Scott, Christopher Marquette | Family, Science fiction | Walt Disney Pictures; based on Escape to Witch Mountain and on Escape to Witch Mountain by Alexander Key |
| The Road | John Hillcoat | Charlize Theron, Viggo Mortensen, Kodi Smit-McPhee, Robert Duvall | Drama, Science fiction | Based on The Road by Cormac McCarthy |
| Saw VI | Kevin Greutert | Tobin Bell, Costas Mandylor, Shawnee Smith, Tanedra Howard, Betsy Russell, Mark Rolston, Peter Outerbridge | Horror | Lionsgate
Preceded by Saw V (2008) |
| A Serious Man | Joel and Ethan Coen | Michael Stuhlbarg, Richard Kind | Comedy | Focus Features |
| Sherlock Holmes | Guy Ritchie | Robert Downey, Jr., Jude Law, Rachel McAdams, Mark Strong | Adventure | Warner Bros. Pictures |
| Shrink | Jonas Pete | Kevin Spacey | Drama | Roadside Attractions |
| Shorts | Robert Rodriguez | Jon Cryer, William H. Macy, Leslie Mann, James Spader, Jimmy Bennett, Kat Dennings | Comedy, Family | Warner Bros. Pictures |
| A Single Man | Tom Ford | Colin Firth, Julianne Moore, Matthew Goode, Nicholas Hoult | Drama | The Weinstein Company |
| The Slammin' Salmon | Kevin Heffernan | Michael Clarke Duncan, Jay Chandrasekhar, Kevin Heffernan, Steve Lemme, Paul Soter, Erik Stolhanske, April Bowlby, Sendhil Ramamurthy, Lance Henriksen, Olivia Munn, Vivica A. Fox, Morgan Fairchild | Comedy | Anchor Bay Films |
| The Soloist | Joe Wright | Jamie Foxx, Robert Downey, Jr. | Bio-pic, Drama | Paramount Pictures, DreamWorks; based on The Soloist by Steve Lopez |
| Sorority Row | Stewart Hendler | Briana Evigan, Jamie Chung, Rumer Willis, Leah Pipes, Audrina Patridge, Matt O'Leary, Julian Morris, Margo Harshman, Matt Lanter, Carrie Fisher | Horror | Summit Entertainment
Based on The House on Sorority Row |
| Spread | David Mackenzie | Ashton Kutcher, Anne Heche, Margarita Levieva, Sebastian Stan, Rachel Blanchard, María Conchita Alonso | Comedy | TVA Films |
| The Star of Bethlehem | Stephen Vidano | Frederick Larson's search for the Star of Bethlehem | Documentary | Mpower Pictures |
| Star Trek | J. J. Abrams | Chris Pine, Zachary Quinto, Karl Urban, Simon Pegg, Zoe Saldana, John Cho, Ben Cross, Anton Yelchin, Winona Ryder, Eric Bana, Leonard Nimoy | Action, Science fiction | Paramount Pictures; preceded by Star Trek Nemesis (2002) |
| State of Play | Kevin Macdonald | Russell Crowe, Ben Affleck, Rachel McAdams, Helen Mirren | Political thriller | Universal Pictures; based on State of Play |
| The Stepfather | Nelson McCormick | Penn Badgley, Dylan Walsh, Amber Heard, Sela Ward, Jon Tenney | Horror | Screen Gems
Based on The Stepfather |
| Street Fighter: The Legend of Chun-Li | Andrzej Bartkowiak | Kristin Kreuk, Chris Klein, Neal McDonough, Robin Shou, Moon Bloodgood, Josie Ho, Taboo, Michael Clarke Duncan | Action, Crime | 20th Century Fox, Hyde Park Entertainment, Capcom; preceded by Street Fighter (1994) |
| Surrogates | Jonathan Mostow | Bruce Willis, Radha Mitchell, Rosamund Pike, Boris Kodjoe, James Cromwell, Ving Rhames | Action, Science fiction | Touchstone Pictures; based on The Surrogates by Robert Venditti |
| The Taking of Pelham 123 | Tony Scott | Denzel Washington, John Travolta, John Turturro, James Gandolfini | Action, Crime | Columbia Pictures, MGM. Based on The Taking of Pelham One Two Three and The Taking of Pelham One Two Three by Morton Freedgood |
| Taking Woodstock | Ang Lee | Demetri Martin, Dan Fogler, Henry Goodman, Jonathan Groff, Eugene Levy, Jeffrey Dean Morgan, Imelda Staunton, Emile Hirsch, Liev Schreiber | Comedy, Musical | Focus Features; based on Taking Woodstock: A True Story of a Riot, a Concert, and a Life by Elliot Tiber and Tom Monte |
| Tekken | Dwight H. Little | Jon Foo, Kelly Overton, Cary-Hiroyuki Tagawa | Fantasy | Based on the Tekken series from Namco |
| Tennessee | Adam Woodley | Ethan Peck, Adam Rothenberg, Mariah Carey, Lance Reddick, Bill Sage | Drama | Vivendi Entertainment |
| Terminator Salvation | McG | Christian Bale, Sam Worthington, Anton Yelchin, Moon Bloodgood, Bryce Dallas Howard, Common, Jadagrace Berry, Helena Bonham Carter, Jane Alexander | Science fiction | The Halcyon Company, Warner Bros., Columbia Pictures; preceded by Terminator 3: Rise of the Machines (2003) |
| Tetro | Francis Ford Coppola | Vincent Gallo | Drama | American Zoetrope |
| The Time Traveler's Wife | Robert Schwentke | Eric Bana, Rachel McAdams | Romantic drama | New Line Cinema; based on The Time Traveler's Wife by Audrey Niffenegger |
| Transformers: Revenge of the Fallen | Michael Bay | Shia LaBeouf, Megan Fox, Josh Duhamel, Tyrese Gibson, John Turturro, Matthew Marsden | Science fiction | Paramount Pictures; preceded by Transformers (2007). co-produced by DreamWorks pictures.
Winner of the Golden Raspberry Award for Worst Picture |
| Trick 'r Treat | Michael Dougherty | Rochelle Aytes, Dylan Baker, Leslie Bibb, Jean-Luc Bilodeau, Brian Cox, Alberto Ghisi, Brett Kelly, Quinn Lord, Britt McKillip, Anna Paquin, Tahmoh Penikett, Lauren Lee Smith | Horror | Warner Bros. Pictures, Legendary Pictures; Direct-to-DVD |
| True Adolescents | Craig Johnson | Mark Duplass, Bret Loehr, Melissa Leo | Comedy | New Video Group |
| Tyson | James Toback | The life and career of Mike Tyson | Documentary | Sony Pictures Classics |
| The Ugly Truth | Robert Luketic | Katherine Heigl, Gerard Butler | Romantic comedy | Columbia Pictures, Lakeshore Entertainment |
| The Unborn | David S. Goyer | Odette Yustman, Gary Oldman, Meagan Good, Cam Gigandet, James Remar, Jane Alexander, Idris Elba, Carla Gugino | Horror | Rogue Pictures |
| Underworld: Rise of the Lycans | Patrick Tatopoulos | Rhona Mitra, Michael Sheen, Bill Nighy, Kevin Grevioux, Shane Brolly, Steven Mackintosh | Horror | Screen Gems, Lakeshore Entertainment. Preceded by Underworld: Evolution (2006) |
| The Uninvited | Thomas Guard, Charles Guard | Emily Browning, Elizabeth Banks, Arielle Kebbel, David Strathairn | Drama, Horror | DreamWorks Pictures. Based on A Tale of Two Sisters |
| Up | Pete Docter, Bob Peterson | Edward Asner, Jordan Nagai, Paul Eiding, Christopher Plummer, Bob Peterson | Animated film | Walt Disney Pictures |
| Up in the Air | Jason Reitman | George Clooney, Vera Farmiga, Anna Kendrick, Danny McBride, Jason Bateman | Comedy-drama | Paramount Pictures; based on Up in the Air by Walter Kirn |
| Wah Do Dem | Ben Chace | Carl Bradshaw, Sean Bones, Kevin Bewersdorf, Norah Jones, | Comedy | |
|
| Watchmen | Zack Snyder | Jeffrey Dean Morgan, Matthew Goode, Patrick Wilson, Malin Åkerman, Billy Crudup, Jackie Earl Haley, Carla Gugino | Superhero | Warner Bros., Paramount Pictures. Based on Watchmen by Alan Moore |
| We Live in Public | Ondi Timoner | The career of Josh Harris | Documentary | Winner of the Grand Jury Prize: Documentary |
| What Goes Up | Jonathan Glatzer | Steve Coogan, Hilary Duff, Josh Peck, Olivia Thirlby, Molly Shannon | Comedy-drama | Sony Pictures Entertainment |
| Whatever Works | Woody Allen | Larry David, Evan Rachel Wood, Patricia Clarkson, Ed Begley, Jr., Conleth Hill, Michael McKean | Comedy, Romance | Sony Pictures Classics |
| Where the Wild Things Are | Spike Jonze | Max Records, Catherine Keener, Mark Ruffalo, Lauren Ambrose, Chris Cooper, James Gandolfini, Catherine O'Hara, Forest Whitaker, Paul Dano | Family, Fantasy | Warner Bros., Legendary Pictures, Village Roadshow Pictures. Based on Where the Wild Things Are by Maurice Sendak |
| Whiteout | Dominic Sena | Kate Beckinsale, Gabriel Macht, Alex O'Loughlin, Columbus Short, Tom Skerritt | Thriller | Warner Bros. Pictures, Dark Castle Entertainment
Based on Whiteout by Greg Rucka and Steve Lieber |
| Whip It | Drew Barrymore | Ellen Page, Marcia Gay Harden, Kristen Wiig, Drew Barrymore, Juliette Lewis, Jimmy Fallon, Daniel Stern | Comedy-drama | Fox Searchlight Pictures, Mandate Pictures. Based on the novel by Shauna Cross |
| World's Greatest Dad | Bobcat Goldthwait | Robin Williams, Alexie Gilmore, Daryl Sabara, Henry Simmons | Black comedy | Magnolia Pictures, Darko Entertainment |
| X Games 3D: The Movie | | Bob Burnquist, Ricky Carmichael, Kyle Loza, Travis Pastrana, Danny Way, Shaun White, Emile Hirsch (narrator) | Documentary, Sports | ESPN Films |
| X-Men Origins: Wolverine | Gavin Hood | Hugh Jackman, Liev Schreiber, Danny Huston, will.i.am, Lynn Collins, Taylor Kitsch, Ryan Reynolds, Dominic Monaghan | Action adventure, Superhero | 20th Century Fox, Marvel Entertainment. Preceded by X-Men: The Last Stand (2006) |
| Year One | Harold Ramis | Jack Black, Michael Cera, Oliver Platt, Hank Azaria, David Cross, Olivia Wilde, June Raphael, Juno Temple, Christopher Mintz-Plasse | Adventure, Comedy | Columbia Pictures |
| The Young Victoria | Jean-Marc Vallée | Emily Blunt, Miranda Richardson, Jim Broadbent | Drama, Romance | Momentum Pictures |
| Zombieland | Ruben Fleischer | Woody Harrelson, Jesse Eisenberg, Emma Stone, Abigail Breslin | Comedy horror | Columbia Pictures |
