List of adverse effects of imatinib
This is a list of adverse effects of the anti-cancer drug imatinib, sorted by frequency of occurrence.[1][2][3][4][5]
Very common
Very common (>10% incidence) adverse effects include:
- Myelosuppression (see below for details)
- Headache
- Nausea
- Vomiting
- Diarrhoea
- Oedema
- Abdominal pain
- Dyspepsia (indigestion)
- Periorbital oedema
- Dermatitis
- Eczema
- Rash
- Muscle spasms or cramps
- Muscle aches
- Joint pain
- Bone pain
- Fatigue
- Weight gain
Common
Common (1–10% incidence) adverse effects include:
- Weight loss
- Insomnia
- Dizziness
- Paresthesias
- Taste disturbance
- Hypoaesthesia
- Lacrimination
- Conjunctivitis
- Dry eye
- Blurred vision
- Flushing
- Haemorrhage
- Dyspnoea
- Epistaxis (nosebleeds)
- Cough
- Flatulence
- Abdominal distension
- Gastro-oesophageal reflux
- Constipation
- Dry mouth
- Gastritis
- Increased hepatic enzymes
- Itchiness
- Dry skin
- Erythema
- Alopecia (hair loss)
- Night sweats
- Photosensitivity reaction
- Joint swelling
- Weakness
- Fever without an infectious cause
- Anasarca
- Chills
- Rigors
Uncommon
Uncommon (0.1–1% incidence) adverse effects include:
- Herpes zoster
- Herpes simplex
- Nasopharyngitis
- Pneumonia
- Sinusitis
- Cellulitis
- Upper respiratory tract infection
- Influenza
- Urinary tract infection
- Gastroenteritis
- Sepsis
- Hypokalaemia
- Increased appetite
- Hypophosphataemia
- Decreased appetite
- Dehydration
- Gout
- Hyperuricaemia
- Hypercalcaemia
- Hyperglycaemia
- Hyponatraemia
- Depression
- Libido decreased
- Anxiety
- Migraine
- Somnolence
- Syncope
- Peripheral neuropathy
- Memory impairment
- Sciatica
- Restless leg syndrome
- Tremor
- Cerebral haemorrhage
- Eye irritation
- Eye pain
- Orbital oedema
- Scleral haemorrhage
- Retinal haemorrhage
- Blepharitis
- Macular oedema
- Vertigo
- Tinnitus
- Hearing loss
- Palpitations
- Tachycardia
- Congestive heart failure
- Pulmonary oedema
- Hypertension
- Haematoma
- Subdural haematoma
- Peripheral coldness
- Hypotension
- Raynaud's phenomenon
- Pleural effusion
- Pharyngolaryngeal pain
- Pharyngitis
- Stomatitis
- Mouth ulceration
- Gastrointestinal haemorrhage
- Eructation
- Melaena
- Oesophagitis
- Ascites
- Gastric ulcer
- Haematemesis
- Cheilitis
- Dysphagia
- Pancreatitis
- Hyperbilirubinaemia
- Hepatitis
- Jaundice
- Pustutular rash
- Contusion
- Increased sweating
- Urticaria
- Ecchymosis
- Increased tendency to bruise
- Hypotrichosis
- Skin hypopigmentation
- Dermatitis exfoliative
- Onychoclasis
- Folliculitis
- Petechiae
- Psoriasis
- Purpura
- Skin hyperpigmentation
- Bullous eruptions
- Joint and/or muscle stiffness
- Renal pain
- Haematuria
- Renal failure
- Increased urinary frequency
- Gynaecomastia
- Erectile dysfunction
- Menorrhagia
- Irregular menstruation
- Sexual dysfunction
- Nipple pain
- Breast enlargement
- Scrotal oedema
- Chest pain
- Malaise
- Blood creatinine increased
- Blood creatine phosphokinase increased
- Blood lactate dehydrogenase increased
- Blood alkaline phosphatase increased
Myelosuppression more commonly occurs in CML patients and includes: thrombocytopenia and neutropenia.[5] Thrombocytopenia usually lasts for 2–3 weeks and neutropenia for 3–4 weeks.[5]
References
- ↑ "Gleevec (imatinib) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 24 January 2014.
- ↑ "GLEEVEC (imatinib mesylate) tablet [Novartis Pharmaceuticals Corporation]". DailyMed. Novartis Pharmaceuticals Corporation. October 2013. Retrieved 24 January 2014.
- ↑ "GLIVEC Tablets - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Novartis Pharmaceuticals UK Ltd.
- ↑ "GLIVEC (imatinib)" (PDF). TGA eBusiness Services. Novartis Pharmaceuticals Australia Pty Ltd. 21 August 2013. Retrieved 24 January 2014.
- 1 2 3 Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
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