METAP1

METAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B3H, 2B3K, 2B3L, 2G6P, 2GZ5, 2NQ6, 2NQ7, 4FLI, 4FLJ, 4FLK, 4FLL, 4HXX, 4IKR, 4IKS, 4IKT, 4IKU, 4IU6, 4U1B, 4U69, 4U6C, 4U6E, 4U6J, 4U6W, 4U6Z, 4U70, 4U71, 4U73, 4U75, 4U76
Identifiers
Aliases	METAP1, MAP1A, MetAP1A, methionyl aminopeptidase 1
External IDs	MGI: 1922874 HomoloGene: 6488 GeneCards: METAP1
Gene ontology Molecular function • peptidase activity • aminopeptidase activity • metalloexopeptidase activity • hydrolase activity • metal ion binding • metalloaminopeptidase activity Cellular component • cytoplasm • cytosol • nucleus • cytosolic ribosome Biological process • peptidyl-methionine modification • platelet aggregation • N-terminal protein amino acid modification • regulation of translation • proteolysis • regulation of rhodopsin mediated signaling pathway • protein initiator methionine removal Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23173	75624
Ensembl	ENSG00000164024	ENSMUSG00000005813
UniProt	P53582	Q8BP48
RefSeq (mRNA)	NM_015143	NM_175224
RefSeq (protein)	NP_055958.2	NP_780433.1
Location (UCSC)	Chr 4: 99 – 99.06 Mb	Chr 3: 138.46 – 138.49 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
4. Dummitt B, Fei Y, Chang YH (Jul 2002). "Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae". Protein Pept Lett. 9 (4): 295–303. doi:10.2174/0929866023408607. PMID 12144506.
5. "Entrez Gene: METAP1 methionyl aminopeptidase 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Serero A, Giglione C, Sardini A, et al. (2004). "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.". J. Biol. Chem. 278 (52): 52953–63. doi:10.1074/jbc.M309770200. PMID 14532271.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Addlagatta A, Hu X, Liu JO, Matthews BW (2006). "Structural basis for the functional differences between type I and type II human methionine aminopeptidases.". Biochemistry. 44 (45): 14741–9. doi:10.1021/bi051691k. PMID 16274222.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Selvakumar P, Lakshmikuttyamma A, Dimmock JR, Sharma RK (2006). "Methionine aminopeptidase 2 and cancer.". Biochim. Biophys. Acta. 1765 (2): 148–54. doi:10.1016/j.bbcan.2005.11.001. PMID 16386852.
• Hu X, Addlagatta A, Lu J, et al. (2007). "Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.". Proc. Natl. Acad. Sci. U.S.A. 103 (48): 18148–53. doi:10.1073/pnas.0608389103. PMC 1838721. PMID 17114291.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.