MLL4

KMT2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UVM, 4ERZ, 4PZI
Identifiers
Aliases	KMT2B, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7, CXXC10, lysine methyltransferase 2B
External IDs	MGI: 109565 HomoloGene: 22838 GeneCards: KMT2B
Gene ontology Molecular function • methyltransferase activity • transferase activity • DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • histone methyltransferase activity (H3-K4 specific) • metal ion binding • protein binding • histone-lysine N-methyltransferase activity Cellular component • nucleoplasm • nucleus • histone methyltransferase complex Biological process • gene silencing • regulation of transcription, DNA-templated • histone H3-K4 trimethylation • regulation of histone H3-K4 methylation • memory • transcription, DNA-templated • histone H3-K4 methylation • methylation • chromatin-mediated maintenance of transcription • ovarian follicle development • histone lysine methylation • ovulation • oocyte differentiation • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9757	75410
Ensembl	ENSG00000272333	ENSMUSG00000006307
UniProt	Q9UMN6	O08550
RefSeq (mRNA)	NM_014727	NM_001290573 NM_029274
RefSeq (protein)	NP_055542.1	NP_083550.2
Location (UCSC)	Chr 19: 35.72 – 35.74 Mb	Chr 7: 30.57 – 30.59 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene.^[3]

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: MLL4 myeloid/lymphoid or mixed-lineage leukemia 4".

Further reading

• Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC 1169838. PMID 9171351.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• FitzGerald KT, Diaz MO (1999). "MLL2: A new mammalian member of the trx/MLL family of genes". Genomics. 59 (2): 187–92. doi:10.1006/geno.1999.5860. PMID 10409430.
• Huntsman DG, Chin SF, Muleris M, et al. (2000). "MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines". Oncogene. 18 (56): 7975–84. doi:10.1038/sj.onc.1203291. PMID 10637508.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• MLL4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.