Molybdopterin adenylyltransferase

Molybdopterin adenylyltransferase
Identifiers
EC number 2.7.7.75
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Molybdopterin adenylyltransferase (EC 2.7.7.75, MogA, Cnx1) is an enzyme with systematic name ATP:molybdopterin adenylyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

ATP + molybdopterin diphosphate + adenylyl-molybdopterin

This enzyme catalyses the activation of molybdopterin for molybdenum insertion.

References

  1. Nichols, J.D.; Rajagopalan, K.V. (2005). "In vitro molybdenum ligation to molybdopterin using purified components". J. Biol. Chem. 280 (9): 7817–7822. doi:10.1074/jbc.M413783200. PMID 15632135.
  2. Kuper, J.; Palmer, T.; Mendel, R.R.; Schwarz, G. (2000). "Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization". Proc. Natl. Acad. Sci. USA. 97 (12): 6475–6480. doi:10.1073/pnas.110568497. PMC 18627Freely accessible. PMID 10823911.
  3. Llamas, A.; Mendel, R.R.; Schwarz, G. (2004). "Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion". J. Biol. Chem. 279 (53): 55241–55246. doi:10.1074/jbc.M409862200. PMID 15504727.
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