ContraPest

ContraPest is a contraceptive pest control product for small mammals such as mice and rats, developed by the U.S. biotechnology company SenesTech.[1][2] It is a flavored liquid, designed to be attractive to, and to be consumed by, the target animals.

The product's original name "Mouseopause" is a play on the words "mouse menopause".[2] The product was approved for commercial use by the U.S. Environmental Protection Agency in August 2016.[3]

ContraPest contains the ovotoxic chemical 4-vinylcyclohexene diepoxide (VCD), which is a known killer of oocytes in immature ovarian follicles.[4][5][6] The rat version of ContraPest also contains triptolide, which the company reports has adverse reproductive effects on both males and females.[1] The product has been successfully used to sterilize both male and female mice, rats, and dogs.[1][2]

References

  1. 1 2 3 "Man v rat: could the long war soon be over?". The Guardian. 2016-09-20. ISSN 0261-3077. Retrieved 2016-09-21.
  2. 1 2 3 Russo, Stephanie (2011-07-21). "Drug may revolutionize control of dog population". archive.azcentral.com. Retrieved 2016-09-21.
  3. ↑ "ContraPest Rodent Control Product Wins EPA Approval". Pest Control Technology, GIA Media, Inc. 12 August 2016. Retrieved 11 November 2016.
  4. ↑ Kappeler, Connie J.; Hoyer, Patricia B. (2012-02-01). "4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity". Systems Biology in Reproductive Medicine. 58 (1): 57–62. doi:10.3109/19396368.2011.648820. ISSN 1939-6376. PMC 3307534Freely accessible. PMID 22239082.
  5. ↑ Takai, Yasushi; Canning, Jacqueline; Perez, Gloria I.; Pru, James K.; Schlezinger, Jennifer J.; Sherr, David H.; Kolesnick, Richard N.; Yuan, Junying; Flavell, Richard A. (2003-01-01). "Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo". Endocrinology. 144 (1): 69–74. doi:10.1210/en.2002-220814. ISSN 0013-7227. PMID 12488331.
  6. ↑ Hoyer, P. B.; Devine, P. J.; Hu, X.; Thompson, K. E.; Sipes, I. G. (2001-02-01). "Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model". Toxicologic Pathology. 29 (1): 91–99. ISSN 0192-6233. PMID 11215690.


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