N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
Identifiers
EC number 2.4.1.141
CAS number 75536-54-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase (EC 2.4.1.141, UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase, uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase, N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol UDP + N,N'-diacetylchitobiosyl-diphosphodolichol

References

  1. Sharma, C.B.; Lehle, L.; Tanner, W. (1982). "Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast". Eur. J. Biochem. 126: 319–325. doi:10.1111/j.1432-1033.1982.tb06781.x. PMID 6215245.
  2. Turco, S.J.; Heath, E.C. (1977). "Glucuronosyl-N-acetylglucosaminyl pyrophosphoryldolichol. Formation in SV40-transformed human lung fibroblasts and biosynthesis in rat lung microsomal preparations". J. Biol. Chem. 252 (9): 2918–2928. PMID 192724.
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