N-acetyltransferase 1

NAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IJA, 2PQT
Identifiers
Aliases	NAT1, AAC1, MNAT, NAT-1, NATI, N-acetyltransferase 1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
External IDs	MGI: 109201 HomoloGene: 37329 GeneCards: NAT1
Gene ontology Molecular function • arylamine N-acetyltransferase activity • transferase activity • acetyltransferase activity • transferase activity, transferring acyl groups Cellular component • cytoplasm • cytosol Biological process • xenobiotic metabolic process • metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9	17961
Ensembl	ENSG00000171428	ENSMUSG00000051147
UniProt	P18440 Q400J6	P50295
RefSeq (mRNA)	NM_000662 NM_001160170 NM_001160171 NM_001160172 NM_001160173 NM_001160174 NM_001160175 NM_001160176 NM_001160179 NM_001291962	NM_001168577 NM_010874
RefSeq (protein)	NP_000653.3 NP_001153642.1 NP_001153643.1 NP_001153644.1 NP_001153645.1 NP_001153646.1 NP_001153651.1 NP_001153642.1 NP_001153644.1 NP_001153645.1 NP_001153646.1 NP_001153647.1	NP_001162049.1 NP_035004.1
Location (UCSC)	Chr 8: 18.17 – 18.22 Mb	Chr 8: 67.49 – 67.5 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene.^[3]

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat NAT2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: N-acetyltransferase 1 (arylamine N-acetyltransferase)". Retrieved 2012-01-27.

Further reading

• Gubin, A. N.; Njoroge, J. M.; Bouffard, G. G.; Miller, J. L. (1999). "Gene Expression in Proliferating Human Erythroid Cells". Genomics. 59 (2): 168–177. doi:10.1006/geno.1999.5855. PMID 10409428.
• Smelt, V. A.; Upton, A.; Adjaye, J.; Payton, M. A.; Boukouvala, S.; Johnson, N.; Mardon, H. J.; Sim, E. (2000). "Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos". Human Molecular Genetics. 9 (7): 1101–1107. doi:10.1093/hmg/9.7.1101. PMID 10767335.
• Brockton, N.; Little, J.; Sharp, L.; Cotton, S. C. (2000). "N-acetyltransferase polymorphisms and colorectal cancer: A HuGE review". American Journal of Epidemiology. 151 (9): 846–861. doi:10.1093/oxfordjournals.aje.a010289. PMID 10791558.
• Lo-Guidice, J. M.; Allorge, D.; Chevalier, D.; Debuysère, H.; Fazio, F.; Lafitte, L. J.; Broly, F. (2000). "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay". Pharmacogenetics. 10 (4): 293–300. doi:10.1097/00008571-200006000-00003. PMID 10862520.
• De León, J. H.; Vatsis, K. P.; Weber, W. W. (2000). "Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1". Molecular Pharmacology. 58 (2): 288–299. PMID 10908296.
• Yu, M. W.; Pai, C. I.; Yang, S. Y.; Hsiao, T. J.; Chang, H. C.; Lin, S. M.; Liaw, Y. F.; Chen, P. J.; Chen, C. J. (2000). "Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: Impact of smoking on risk". Gut. 47 (5): 703–709. doi:10.1136/gut.47.5.703. PMC 1728099. PMID 11034589.
• Wikman, H.; Thiel, S.; Jäger, B.; Schmezer, P.; Spiegelhalder, B.; Edler, L.; Dienemann, H.; Kayser, K.; Schulz, V.; Drings, P.; Bartsch, H.; Risch, A. (2001). "Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility". Pharmacogenetics. 11 (2): 157–168. doi:10.1097/00008571-200103000-00006. PMID 11266080.
• Krajinovic, M.; Ghadirian, P.; Richer, C.; Sinnett, H.; Gandini, S.; Perret, C.; Lacroix, A.; Labuda, D.; Sinnett, D. (2001). "Genetic susceptibility to breast cancer in French-Canadians: Role of carcinogen-metabolizing enzymes and gene-environment interactions". International Journal of Cancer. 92 (2): 220–225. doi:10.1002/1097-0215(200102)9999:9999<::AID-IJC1184>3.0.CO;2-H. PMID 11291049.
• Sekine, A.; Saito, A.; Iida, Y.; Mitsunobu, S.; Higuchi, S.; Harigae, Y.; Nakamura, S. (2001). "Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1 , NAT2 , AANAT , ARD1 , and L1CAM in the Japanese population". Journal of Human Genetics. 46 (6): 314–319. doi:10.1007/s100380170065. PMID 11393533.
• Butler, W. J.; Ryan, P.; Roberts-Thomson, I. C. (June 2001). "Metabolic genotypes and risk for colorectal cancer". J. Gastroenterol. Hepatol. 16 (6): 631–635. doi:10.1046/j.1440-1746.2001.02501.x. PMID 11422615.