NEDD1

NEDD1
Identifiers
Aliases	NEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1
External IDs	MGI: 97293 HomoloGene: 7439 GeneCards: NEDD1
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	121441	17997
Ensembl	ENSG00000139350	ENSMUSG00000019988
UniProt	Q8NHV4	P33215
RefSeq (mRNA)	NM_001135175 NM_001135176 NM_001135177 NM_152905	NM_008682
RefSeq (protein)	NP_001128647.1 NP_001128648.1 NP_001128649.1 NP_690869.1	NP_032708.2
Location (UCSC)	Chr 12: 96.91 – 96.95 Mb	Chr 10: 92.68 – 92.72 Mb
PubMed search	[1]	[2]
Wikidata

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Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene ^[3] and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

Further reading

• Pinyol R, Scrofani J, Vernos I (2012). "The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.". Curr Biol. 23 (2): 143–9. doi:10.1016/j.cub.2012.11.046. PMID 23273898.
• Sdelci S, Schütz M, Pinyol R, et al. (2012). "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.". Curr Biol. 22 (16): 1516–23. doi:10.1016/j.cub.2012.06.027. PMID 22818914.
• Haren L, Remy MH, Bazin I, et al. (2006). "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly.". J. Cell Biol. 172 (4): 505–15. doi:10.1083/jcb.200510028. PMC 2063671. PMID 16461362.
• Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.". Nat. Cell Biol. 8 (2): 137–47. doi:10.1038/ncb1349. PMID 16378099.
• Jung SY, Malovannaya A, Wei J, et al. (2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.". Mol. Endocrinol. 19 (10): 2451–65. doi:10.1210/me.2004-0476. PMID 16051665.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization.". Hum. Genet. 95 (1): 96–8. doi:10.1007/BF00225082. PMID 7814034.