NELL1

NELL1
Identifiers
Aliases NELL1, IDH3GL, NRP1, neural EGFL like 1
External IDs MGI: 2443902 HomoloGene: 4486 GeneCards: NELL1
Genetically Related Diseases
Crohn's disease[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

4745

338352

Ensembl

ENSG00000165973

ENSMUSG00000055409

UniProt

Q92832

Q2VWQ2

RefSeq (mRNA)

NM_001288713
NM_001288714
NM_006157
NM_201551

NM_001037906

RefSeq (protein)

NP_001275642.1
NP_001275643.1
NP_006148.2
NP_963845.1

NP_001032995.1

Location (UCSC) Chr 11: 20.67 – 21.58 Mb Chr 7: 49.97 – 50.87 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.[4][5][6]

Function

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.[5]

Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.[6]

References

  1. "Diseases that are genetically associated with NELL1 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E (Mar 1997). "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats". Genomics. 38 (3): 273–6. doi:10.1006/geno.1996.0628. PMID 8975702.
  5. 1 2 "Entrez Gene: NELL1 NEL-like 1 (chicken)".
  6. 1 2 "Study reveals bone-building protein's impact on bone stem cells".

Further reading


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