Nidogen-1

NID1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NDX
Identifiers
Aliases	NID1, NID, nidogen 1
External IDs	OMIM: 131390 MGI: 97342 HomoloGene: 1878 GeneCards: NID1
Gene ontology Molecular function • laminin-1 binding • calcium ion binding • laminin binding • collagen binding • extracellular matrix binding • proteoglycan binding Cellular component • extracellular matrix • proteinaceous extracellular matrix • extracellular region • basement membrane • extracellular exosome • cell periphery • basal lamina Biological process • cell-matrix adhesion • extracellular matrix disassembly • extracellular matrix organization • cell adhesion • glomerular basement membrane development • basement membrane organization • positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4811	18073
Ensembl	ENSG00000116962	ENSMUSG00000005397
UniProt	P14543	P10493
RefSeq (mRNA)	NM_002508	NM_010917
RefSeq (protein)	NP_002499.2	NP_035047.2
Location (UCSC)	Chr 1: 235.98 – 236.07 Mb	Chr 13: 13.44 – 13.51 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Nidogen-1 (NID-1), formerly known as entactin, is a protein that in humans is encoded by the NID1 gene.^[3][4] Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin^[5] and fibronectin.^[6]

Function

Nidogen-1 is a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes. Structurally it (along with perlecan) connects the networks formed by collagens and laminins to each other.^[7] It may also play a role in cell interactions with the extracellular matrix.^[8][9]

Interactions

Nidogen-1 has been shown to interact with FBLN1.^[10][11][12]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Olsen DR, Nagayoshi T, Fazio M, Mattei MG, Passage E, Weil D, Timpl R, Chu ML, Uitto J (June 1989). "Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome Iq43". Am. J. Hum. Genet. 44 (6): 876–85. PMC 1715653. PMID 2471408.
4. Zimmermann K, Hoischen S, Hafner M, Nischt R (May 1995). "Genomic sequences and structural organization of the human nidogen gene (NID)". Genomics. 27 (2): 245–50. doi:10.1006/geno.1995.1038. PMID 7557988.
5. Smith J, Ockleford CD (January 1994). "Laser scanning confocal examination and comparison of nidogen (entactin) with laminin in term human amniochorion". Placenta. 15 (1): 95–106. doi:10.1016/S0143-4004(05)80240-1. PMID 8208674.
6. Ockleford CD, Bright N, Hubbard A, D'Lacey C, Smith J, Gardiner L, Sheikh T, Albentosa M, Turtle K (October 1993). "Micro-Trabeculae, Macro-Plaques or Mini-Basement Membranes in Human Term Fetal Membranes?". Phil. Trans. R. Soc. Lond. B. 342 (1300): 121–136. doi:10.1098/rstb.1993.0142.
7. Yurchenco PD, Patton BL (2009). "Developmental and pathogenic mechanisms of basement membrane assembly". Curr. Pharm. Des. 15 (12): 1277–94. doi:10.2174/138161209787846766. PMC 2978668. PMID 19355968.
8. "Entrez Gene: NID1 nidogen 1".
9. Yi XY, Wayner EA, Kim Y, Fish AJ (March 1998). "Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors". Cell Adhes. Commun. 5 (3): 237–48. doi:10.3109/15419069809040294. PMID 9686320.
10. Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G (September 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules". J. Mol. Biol. 272 (2): 226–36. doi:10.1006/jmbi.1997.1244. PMID 9299350.
11. Tran H, VanDusen WJ, Argraves WS (September 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains". J. Biol. Chem. 272 (36): 22600–6. doi:10.1074/jbc.272.36.22600. PMID 9278415.
12. Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML (August 1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands". Eur. J. Biochem. 215 (3): 733–40. doi:10.1111/j.1432-1033.1993.tb18086.x. PMID 8354280.

Further reading

• Chung AE, Durkin ME (1990). "Entactin: structure and function.". Am. J. Respir. Cell Mol. Biol. 3 (4): 275–82. doi:10.1165/ajrcmb/3.4.275. PMID 2119632.
• Yurchenco PD, Schittny JC (1990). "Molecular architecture of basement membranes.". FASEB J. 4 (6): 1577–90. PMID 2180767.

External links

• Nidogen at the US National Library of Medicine Medical Subject Headings (MeSH)