NLRC3

NLRC3
Identifiers
Aliases NLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3
External IDs MGI: 2444070 HomoloGene: 18720 GeneCards: NLRC3
Orthologs
Species Human Mouse
Entrez

197358

268857

Ensembl

ENSG00000167984

ENSMUSG00000049871

UniProt

Q7RTR2

Q5DU56

RefSeq (mRNA)

NM_178844

NM_001081280
NM_175547

RefSeq (protein)

NP_849172.2

NP_780756.1

Location (UCSC) Chr 16: 3.54 – 3.58 Mb Chr 16: 3.95 – 3.98 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[3] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772Freely accessible. PMID 18341998.
  4. Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.


This article is issued from Wikipedia - version of the 6/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.