NOVA1

NOVA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases NOVA1, Nova-1, NOVA alternative splicing regulator 1
External IDs MGI: 104297 HomoloGene: 21296 GeneCards: NOVA1
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

4857

664883

Ensembl

ENSG00000139910

ENSMUSG00000021047

UniProt

P51513

Q9JKN6

RefSeq (mRNA)

NM_002515
NM_006489
NM_006491

NM_021361

RefSeq (protein)

NP_002506.2
NP_006480.2
NP_006482.1

NP_067336.1

Location (UCSC) Chr 14: 26.44 – 26.6 Mb Chr 12: 46.69 – 46.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.[3][4]

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Buckanovich RJ, Yang YY, Darnell RB (Feb 1996). "The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies". J Neurosci. 16 (3): 1114–22. PMID 8558240.
  4. 1 2 "Entrez Gene: NOVA1 neuro-oncological ventral antigen 1".

Further reading


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