Naftifine
Clinical data | |
---|---|
Trade names | Exoderil |
AHFS/Drugs.com | Monograph |
MedlinePlus | a688020 |
ATC code | D01AE22 (WHO) |
Identifiers | |
| |
CAS Number | 65472-88-0 |
PubChem (CID) | 47641 |
DrugBank | DB00735 |
ChemSpider | 66071 |
UNII | 4FB1TON47A |
ChEBI | CHEBI:7451 |
ChEMBL | CHEMBL626 |
Chemical and physical data | |
Formula | C21H21N |
Molar mass | 287.398 g/mol |
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Naftifine (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).
Naftifine has triple action: antifungal, antibacterial and anti-inflammatory. Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.[1][2] The half-life is approximately 2–3 days.[2] The metabolites are excreted in the urine and feces.[3]
References
- ↑ Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
- 1 2 Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010.
- ↑ AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620§ion=10, February 18, 2010.
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