Natalie Strynadka

Natalie Strynadka
Natalie Strynadka in 2015, portrait via the Royal Society
Born	Natalie C. J. Strynadka 1963 (age 52–53)[1]
Fields	Biochemistry Bacterial cell structure[2][3] Beta-lactamase inhibitor proteins[4][5]
Institutions	University of British Columbia Howard Hughes Medical Institute
Alma mater	University of Alberta (BSc, PhD)
Thesis	Probing molecular interactions at various levels of structural definition (1990)
Doctoral advisor	Michael N. G. James[6]
Doctoral students	Andrew Alexander Brianne Burkinshaw[7] Dustin King[8] Franco Li Matt Solomonson[9] Sean Workman[10]
Notable awards	FRS (2015)[11]
Website strynadkalab.biochem.ubc.ca www.hhmi.org/scientists/natalie-cj-strynadka

Natalie C. J. Strynadka FRS^[11] is a Professor of Biochemistry in the Department of Biochemistry and Molecular Biology at the University of British Columbia.^{[12][13][14][15][16]}

Education

Strynadka was educated at the University of Alberta where she was awarded a PhD in 1990.^[17] Her thesis committee included Michael N.G. James and Sir David Chilton Phillips.^[17]

Awards and honours

Strynadka was elected a Fellow of the Royal Society (FRS) in 2015. Her certificate of election reads:^[11]

Natalie Strynadka is a pioneer in the study of proteins and protein assemblies essential to bacterial pathogenicity and antibiotic resistance. Her agenda-setting dissection of the membrane assemblies involved in infection, virulence and bacterial cell wall synthesis is having major impact in the development of therapeutic agents; both antibiotics and vaccines.

References

1. Natalie Strynadka VIAF: 105554096
2. Lovering, A. L.; De Castro, L. H.; Lim, D; Strynadka, N. C. (2007). "Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis". Science. 315 (5817): 1402–5. doi:10.1126/science.1136611. PMID 17347437.
3. Wilke, M. S.; Heller, M; Creagh, A. L.; Haynes, C. A.; McIntosh, L. P.; Poole, K; Strynadka, N. C. (2008). "The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR". Proceedings of the National Academy of Sciences. 105 (39): 14832–7. doi:10.1073/pnas.0805489105. PMC 2567453. PMID 18812515.
4. Strynadka, N. C.; Jensen, S. E.; Johns, K; Blanchard, H; Page, M; Matagne, A; Frère, J. M.; James, M. N. (1994). "Structural and kinetic characterization of a beta-lactamase-inhibitor protein". Nature. 368 (6472): 657–60. doi:10.1038/368657a0. PMID 8145854.
5. King, A. M.; Reid-Yu, S. A.; Wang, W; King, D. T.; De Pascale, G; Strynadka, N. C.; Walsh, T. R.; Coombes, B. K.; Wright, G. D. (2014). "Aspergillomarasmine a overcomes metallo-β-lactamase antibiotic resistance". Nature. 510 (7506): 503–6. doi:10.1038/nature13445. PMID 24965651.
6. Strynadka, N. C. J.; James, M. N. G. (1989). "Crystal Structures of the Helix-Loop-Helix Calcium-Binding Proteins". Annual Review of Biochemistry. 58: 951–98. doi:10.1146/annurev.bi.58.070189.004511. PMID 2673026.
7. Burkinshaw, B. J.; Deng, W; Lameignère, E; Wasney, G. A.; Zhu, H; Worrall, L. J.; Finlay, B. B.; Strynadka, N. C. (2015). "Structural Analysis of a Specialized Type III Secretion System Peptidoglycan-cleaving Enzyme". Journal of Biological Chemistry. 290 (16): 10406–17. doi:10.1074/jbc.M115.639013. PMC 4400350. PMID 25678709.
8. King, D. T.; Lameignere, E; Strynadka, N. C. (2014). "Structural insights into the lipoprotein outer membrane regulator of penicillin-binding protein 1B". Journal of Biological Chemistry. 289 (27): 19245–53. doi:10.1074/jbc.M114.565879. PMC 4081958. PMID 24808177.
9. Solomonson, M; Huesgen, P. F.; Wasney, G. A.; Watanabe, N; Gruninger, R. J.; Prehna, G; Overall, C. M.; Strynadka, N. C. (2013). "Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system". Journal of Biological Chemistry. 288 (24): 17782–90. doi:10.1074/jbc.M113.462036. PMC 3682577. PMID 23620593.
10. "People in the Strynadka lab". University of British Columbia. Archived from the original on 2014-02-26.
11. "Professor Natalie Strynadka FRS". London: The Royal Society. Archived from the original on 2015-05-12.
12. Strynadka, N. C.; Adachi, H; Jensen, S. E.; Johns, K; Sielecki, A; Betzel, C; Sutoh, K; James, M. N. (1992). "Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 a resolution". Nature. 359 (6397): 700–5. doi:10.1038/359700a0. PMID 1436034.
13. Paetzel, M; Karla, A; Strynadka, N. C.; Dalbey, R. E. (2002). "Signal peptidases". Chemical Reviews. 102 (12): 4549–80. doi:10.1021/cr010166y. PMID 12475201.
14. Gao, S; Kinzig, K. P.; Aja, S; Scott, K. A.; Keung, W; Kelly, S; Strynadka, K; Chohnan, S; Smith, W. W.; Tamashiro, K. L.; Ladenheim, E. E.; Ronnett, G. V.; Tu, Y; Birnbaum, M. J.; Lopaschuk, G. D.; Moran, T. H. (2007). "Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake". Proceedings of the National Academy of Sciences. 104 (44): 17358–63. doi:10.1073/pnas.0708385104. PMC 2077261. PMID 17956983.
15. Zarivach, R; Deng, W; Vuckovic, M; Felise, H. B.; Nguyen, H. V.; Miller, S. I.; Finlay, B. B.; Strynadka, N. C. (2008). "Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS". Nature. 453 (7191): 124–7. doi:10.1038/nature06832. PMID 18451864.
16. Natalie Strynadka's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
17. Strynadka, Natalie C. J. (1990). Probing molecular interactions at various levels of structural definition (PhD thesis). University of Alberta. OCLC 70312424.