Nitric oxide synthase 2 (inducible)

NOS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Identifiers
Aliases	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs	MGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Genetically Related Diseases
psoriasis[1]
Targeted by Drug
pimagedine, nitroarginine, 2-amino-4-methylpyridine[2]
Gene ontology Molecular function • FMN binding • protein homodimerization activity • flavin adenine dinucleotide binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • protein binding • heme binding • NADP binding • oxidoreductase activity • receptor binding • nitric-oxide synthase activity Cellular component • cytoplasm • cytosol • cortical cytoskeleton • peroxisome • intracellular • perinuclear region of cytoplasm • nucleus Biological process • positive regulation of guanylate cyclase activity • response to hypoxia • nitric oxide biosynthetic process • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • negative regulation of protein catabolic process • regulation of insulin secretion • negative regulation of blood pressure • regulation of cytokine production involved in inflammatory response • positive regulation of vasodilation • positive regulation of killing of cells of other organism • negative regulation of gene expression • cell redox homeostasis • arginine catabolic process • prostaglandin secretion • interleukin-6 secretion • response to lipopolysaccharide • cellular response to drug • innate immune response in mucosa • regulation of cell proliferation • peptidyl-cysteine S-nitrosylation • defense response to bacterium • circadian rhythm • defense response to Gram-negative bacterium • nitric oxide mediated signal transduction • interleukin-8 secretion • cellular response to interferon-gamma • regulation of cellular respiration • cellular response to lipopolysaccharide • oxidation-reduction process • superoxide metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4843	18126
Ensembl	ENSG00000007171	ENSMUSG00000020826
UniProt	P35228	P29477
RefSeq (mRNA)	NM_000625 NM_153292	NM_010927 NM_001313921 NM_001313922
RefSeq (protein)	NP_000616.3	NP_001300850.1 NP_001300851.1 NP_035057.1
Location (UCSC)	Chr 17: 27.76 – 27.8 Mb	Chr 11: 78.92 – 78.96 Mb
PubMed search	[3]	[4]
Wikidata

View/Edit Human

View/Edit Mouse

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.^[5]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[6]

Interactions

Nitric oxide synthase 2A has been shown to interact with Caveolin 1^[7] and Rac2.^[8]

References

1. "Diseases that are genetically associated with NOS2 view/edit references on wikidata".
2. "Drugs that physically interact with Nitric oxide synthase, inducible view/edit references on wikidata".
3. "Human PubMed Reference:".
4. "Mouse PubMed Reference:".
5. Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (May 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc Natl Acad Sci USA. 90 (8): 3491–5. doi:10.1073/pnas.90.8.3491. PMC 46326. PMID 7682706.
6. "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)".
7. Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF (December 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14334–9. doi:10.1073/pnas.250406797. PMC 18919. PMID 11114180.
8. Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326–36. PMID 11457725.