OSBPL8

OSBPL8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V88
Identifiers
Aliases	OSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
External IDs	MGI: 2443807 HomoloGene: 68813 GeneCards: OSBPL8
Gene ontology Molecular function • phosphatidylserine binding • phospholipid transporter activity • cholesterol binding • phosphatidylinositol-4-phosphate binding • lipid binding Cellular component • integral component of membrane • nuclear membrane • endoplasmic reticulum membrane • membrane • cortical endoplasmic reticulum • endoplasmic reticulum • nucleus Biological process • activation of protein kinase B activity • positive regulation of protein kinase B signaling • lipid transport • protein localization to nuclear pore • phospholipid transport • positive regulation of glucose import in response to insulin stimulus • negative regulation of cell migration • negative regulation of sequestering of triglyceride • transport • positive regulation of insulin receptor signaling pathway • fat cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	114882	237542
Ensembl	ENSG00000091039	ENSMUSG00000020189
UniProt	Q9BZF1	B9EJ86
RefSeq (mRNA)	NM_001003712 NM_020841 NM_001319652 NM_001319653 NM_001319655	NM_001003717 NM_175489
RefSeq (protein)	NP_001003712.1 NP_065892.1 NP_001306581.1 NP_001306584.1	NP_001003717.1 NP_780698.2
Location (UCSC)	Chr 12: 76.35 – 76.56 Mb	Chr 10: 111.16 – 111.3 Mb
PubMed search	[1]	[2]
Wikidata

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Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.^[3][4][5]

This gene encodes a member of the oxysterol-binding calorie (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Pritchett JW (Mar 1992). "Longitudinal growth and growth-plate activity in the lower extremity". Clin Orthop Relat Res (275): 274–9. doi:10.1097/00003086-199202000-00041. PMID 1735225.
4. Yan D, Mayranpaa MI, Wong J, Perttila J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM (Dec 2007). "OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages". J Biol Chem. 283 (1): 332–40. doi:10.1074/jbc.M705313200. PMID 17991739.
5. "Entrez Gene: OSBPL8 oxysterol binding protein-like 8".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans.". J. Lipid Res. 42 (8): 1203–13. PMID 11483621.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.