Iohexol

Iohexol

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	Intrathecal, intravascular, oral, intracavital, rectal
ATC code	V08AB02 (WHO)
Legal status
Legal status	℞ (Prescription only)
Pharmacokinetic data
Protein binding	Low
Metabolism	Nil
Biological half-life	Variable
Excretion	Renal, unchanged
Identifiers
IUPAC name 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
Synonyms	5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide
CAS Number	66108-95-0
PubChem (CID)	3730
DrugBank	DB01362
ChemSpider	3599
UNII	4419T9MX03
KEGG	D01817
ChEBI	CHEBI:31709
ChEMBL	CHEMBL1200455
ECHA InfoCard	100.060.130
Chemical and physical data
Formula	C19H26I3N3O9
Molar mass	821.138 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(N(c1c(I)c(c(I)c(c1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)CC(O)CO)C
InChI InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34) Key:NTHXOOBQLCIOLC-UHFFFAOYSA-N
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Iohexol is a contrast agent, sold under the trade names Omnipaque and Exypaque; this compound is also sold as a density gradient medium under the names Accudenz, Histodenz and Nycodenz.^[1][2] It is available in various concentrations, from 140 to 350 milligrams of iodine per milliliter. Omnipaque 350 is commonly used as a contrast agent during coronary angiography.

The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood.^[3] Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.^[4]

References

1. "HistoDenz (D2158)", product information sheet, Sigma-Aldrich. Accessed on line Nov. 19, 2015.
2. "Nycodenz®: A universal density gradient medium", Axis-Shield Density Gradient Media. Accessed on line Nov. 19, 2015.
3. GE Healthcare (May 2006). "Omnipaque (Iohexol) injection. Product label". DailyMed. U.S. National Library of Medicine. Retrieved 2007-03-28.
4. Amersham Health (April 2006). "Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label". DailyMed. U.S. National Library of Medicine. Retrieved 2007-03-29.

External links

• Omnipaque (Iohexol) injection, solution