Oxyclozanide
Names | |
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IUPAC name
2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide | |
Identifiers | |
2277-92-1 | |
3D model (Jmol) | Interactive image |
ChemSpider | 15904 |
ECHA InfoCard | 100.017.186 |
KEGG | D08320 |
PubChem | 16779 |
UNII | 1QS9G4876X |
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Properties | |
C13H6Cl5NO3 | |
Molar mass | 401.45 g·mol−1 |
Pharmacology | |
QP52AG06 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes.[1] Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".[2]
References
- ↑ CID 16779 from PubChem
- ↑ Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Conery, Annie L.; Kim, Wooseong; Jayamani, Elamparithi; Kwon, Bumsup; Ausubel, Frederick M.; Mylonakis, Eleftherios (2015). "Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus". PLoS ONE. 10 (4): e0124595. doi:10.1371/journal.pone.0124595. PMC 4405337. PMID 25897961.
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