PAG1

PAG1
Identifiers
Aliases	PAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDs	MGI: 2443160 HomoloGene: 10198 GeneCards: PAG1
Gene ontology Molecular function • SH2 domain binding • protein binding • SH3/SH2 adaptor activity • transmembrane receptor protein tyrosine kinase adaptor activity Cellular component • integral component of membrane • membrane raft • plasma membrane • membrane • integral component of plasma membrane • intracellular Biological process • intracellular signal transduction • T cell receptor signaling pathway • adaptive immune response • epidermal growth factor receptor signaling pathway • regulation of T cell activation • signal transduction • immune system process • positive regulation of signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of T cell activation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55824	94212
Ensembl	ENSG00000076641	ENSMUSG00000027508
UniProt	Q9NWQ8	Q3U1F9
RefSeq (mRNA)	NM_018440	NM_001195031 NM_053182
RefSeq (protein)	NP_060910.3	NP_001181960.1 NP_444412.2
Location (UCSC)	Chr 8: 80.97 – 81.11 Mb	Chr 3: 9.69 – 9.83 Mb
PubMed search	[1]	[2]
Wikidata

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Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.^[3][4]

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.^[4]

Interactions

PAG1 has been shown to interact with FYN,^[3] C-src tyrosine kinase,^[3] Sodium-hydrogen antiporter 3 regulator 1^[5] and Abl gene.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". J Exp Med. 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442. PMID 10790433.
4. "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1".
5. Brdicková, N; Brdicka T; Andera L; Spicka J; Angelisová P; Milgram S L; Horejsí V (Oct 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. Netherlands. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. ISSN 0014-5793. PMID 11684085.
6. Wen, S T; Van Etten R A (Oct 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes Dev. UNITED STATES. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. ISSN 0890-9369. PMC 316562. PMID 9334312.

Further reading

• Wen ST, Van Etten RA (1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.". Genes Dev. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.
• Brdicková N, Brdicka T, Andera L, et al. (2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton.". FEBS Lett. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers.". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
• Jiang LQ, Feng X, Zhou W, et al. (2006). "Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation.". Oncogene. 25 (40): 5495–506. doi:10.1038/sj.onc.1209554. PMID 16636672.
• Takeuchi S (2007). "Expression and purification of human PAG, a transmembrane adapter protein using an insect cell expression system and its structure basis.". Protein J. 25 (4): 295–9. doi:10.1007/s10930-006-9015-6. PMID 16947079.
• Roberts AE, Araki T, Swanson KD, et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome.". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
• Smida M, Posevitz-Fejfar A, Horejsi V, et al. (2007). "A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation.". Blood. 110 (2): 596–615. doi:10.1182/blood-2006-07-038752. PMID 17389760.