PANK1

PANK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases PANK1, PANK, pantothenate kinase 1
External IDs MGI: 1922985 HomoloGene: 56979 GeneCards: PANK1
Orthologs
Species Human Mouse
Entrez

53354

75735

Ensembl

ENSG00000152782

ENSMUSG00000033610

UniProt

Q8TE04

Q8K4K6

RefSeq (mRNA)

NM_138316
NM_148977
NM_148978

NM_001114339
NM_023792

RefSeq (protein)

NP_612189.2
NP_683878.1
NP_683879.1

NP_001107811.1
NP_076281.1

Location (UCSC) Chr 10: 89.58 – 89.65 Mb Chr 19: 34.81 – 34.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.[3]

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.[3]

References

Further reading


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