PANK4

PANK4
Identifiers
Aliases	PANK4
External IDs	MGI: 2387466 HomoloGene: 41235 GeneCards: PANK4
Genetically Related Diseases
obesity[1]
Gene ontology Molecular function • transferase activity • nucleotide binding • pantothenate kinase activity • ATP binding • kinase activity Cellular component • cytoplasm Biological process • coenzyme A biosynthetic process • phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55229	269614
Ensembl	n/a	ENSMUSG00000029056
UniProt	Q9NVE7	Q80YV4
RefSeq (mRNA)	NM_018216	NM_172990 NM_001305804
RefSeq (protein)	NP_060686.2	NP_001292733.1 NP_766578.2
Location (UCSC)	Chr 1: 2.51 – 2.53 Mb	Chr 4: 154.96 – 154.98 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Pantothenate kinase 4 is an enzyme that in humans is encoded by the PANK4 gene.^[4][5]

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.^[5]

References

1. "Diseases that are genetically associated with PANK4 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ (Jul 2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594.
5. "Entrez Gene: PANK4 pantothenate kinase 4".

Further reading

• Robishaw JD, Neely JR (1985). "Coenzyme A metabolism.". Am. J. Physiol. 248 (1 Pt 1): E1–9. PMID 2981478.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Li Y, Chang Y, Zhang L, et al. (2005). "High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2).". Mol. Cell. Biochem. 277 (1-2): 117–25. doi:10.1007/s11010-005-5535-1. PMID 16132722.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.