PARP3

PARP3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EOC, 3C49, 3C4H, 3CE0, 3FHB, 4GV0, 4GV2, 4GV4, 4L6Z, 4L70, 4L7L, 4L7N, 4L7O, 4L7P, 4L7R, 4L7U
Identifiers
Aliases	PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3, poly(ADP-ribose) polymerase family member 3
External IDs	MGI: 1891258 HomoloGene: 4005 GeneCards: PARP3
Gene ontology Molecular function • transferase activity • transferase activity, transferring glycosyl groups • catalytic activity • NAD+ ADP-ribosyltransferase activity • DNA ligase (ATP) activity Cellular component • cytoplasm • site of double-strand break • centriole • cytoskeleton • nucleus • microtubule organizing center Biological process • protein localization to site of double-strand break • DNA ligation involved in DNA repair • lagging strand elongation • regulation of mitotic spindle organization • positive regulation of DNA ligation • telomere maintenance • double-strand break repair • protein ADP-ribosylation • DNA repair Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10039	235587
Ensembl	ENSG00000041880	ENSMUSG00000023249
UniProt	Q9Y6F1	n/a
RefSeq (mRNA)	NM_001003931 NM_001003935 NM_005485	NM_145619 NM_001311150
RefSeq (protein)	NP_001003931.3 NP_005476.4	n/a
Location (UCSC)	Chr 3: 51.94 – 51.95 Mb	Chr 9: 106.47 – 106.48 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.^[3][4]

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues". Genomics. 57 (3): 442–5. doi:10.1006/geno.1999.5799. PMID 10329013.
4. "Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3".

Further reading

• Bashford CL, Chance B, Lloyd D, Poole RK (1981). "Oscillations of redox states in synchronously dividing cultures of Acanthamoeba castellanii and Schizosaccharomyces pombe.". Biophys. J. 29 (1): 1–11. Bibcode:1980BpJ....29....1B. doi:10.1016/S0006-3495(80)85114-9. PMC 1328658. PMID 7260241.
• Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex.". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
• Berghammer H, Ebner M, Marksteiner R, Auer B (1999). "pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans.". FEBS Lett. 449 (2–3): 259–63. doi:10.1016/S0014-5793(99)00448-2. PMID 10338144.
• Still IH, Vince P, Cowell JK (2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein.". Genomics. 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Glowacki G, Braren R, Cetkovic-Cvrlje M, et al. (2001). "Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5.". Gene. 275 (2): 267–77. doi:10.1016/S0378-1119(01)00608-4. PMID 11587854.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Augustin A, Spenlehauer C, Dumond H, et al. (2004). "PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.". J. Cell. Sci. 116 (Pt 8): 1551–62. doi:10.1242/jcs.00341. PMID 12640039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Rouleau M, McDonald D, Gagné P, et al. (2007). "PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.". J. Cell. Biochem. 100 (2): 385–401. doi:10.1002/jcb.21051. PMID 16924674.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Lehtiö L, Jemth AS, Collins R, et al. (2009). "Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.". J. Med. Chem. 52 (9): 3108–3111. doi:10.1021/jm900052j. PMID 19354255.

External links

• PARP3 human gene location in the UCSC Genome Browser.
• PARP3 human gene details in the UCSC Genome Browser.