PARVB

PARVB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EDL, 4EDM, 4EDN
Identifiers
Aliases	PARVB, CGI-56, parvin beta
External IDs	MGI: 2153063 HomoloGene: 8342 GeneCards: PARVB
Genetically Related Diseases
Alzheimer's disease, fatty liver disease[1]
Gene ontology Molecular function • actin binding • protein binding Cellular component • cytoplasm • cytosol • cell junction • plasma membrane • cell projection • sarcomere • Z disc • cytoskeleton • membrane • focal adhesion • lamellipodium Biological process • actin cytoskeleton reorganization • cell adhesion • cell projection assembly • lamellipodium assembly • establishment or maintenance of cell polarity regulating cell shape Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29780	170736
Ensembl	ENSG00000188677	ENSMUSG00000022438
UniProt	Q9HBI1	Q9ES46
RefSeq (mRNA)	NM_001003828 NM_001243385 NM_001243386 NM_013327	NM_133167
RefSeq (protein)	NP_001003828.1 NP_001230314.1 NP_001230315.1 NP_037459.2	NP_573395.1
Location (UCSC)	Chr 22: 44 – 44.17 Mb	Chr 15: 84.23 – 84.32 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Beta-parvin is a protein that in humans is encoded by the PARVB gene.^[4][5][6]

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]^[6]

References

1. "Diseases that are genetically associated with PARVB view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
5. Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. PMID 11171322.
6. "Entrez Gene: PARVB parvin, beta".

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.". J. Cell Biol. 153 (6): 1251–64. doi:10.1083/jcb.153.6.1251. PMC 2192033. PMID 11402068.
• Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans.". Gene. 279 (1): 69–79. doi:10.1016/S0378-1119(01)00743-0. PMID 11722847.
• Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation.". Biochem. Biophys. Res. Commun. 297 (5): 1324–31. doi:10.1016/S0006-291X(02)02381-1. PMID 12372433.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor.". Genes Cells. 9 (3): 193–204. doi:10.1111/j.1356-9597.2004.00717.x. PMID 15005707.
• Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.". J. Cell Biol. 165 (4): 539–51. doi:10.1083/jcb.200308141. PMC 2172344. PMID 15159419.
• Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival.". J. Biol. Chem. 279 (40): 41695–705. doi:10.1074/jbc.M401563200. PMID 15284246.
• Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer.". Oncogene. 23 (55): 8959–70. doi:10.1038/sj.onc.1208112. PMID 15467740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma.". J. Neuropathol. Exp. Neurol. 64 (4): 334–40. PMID 15835269.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.